Eiichi Imai

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A novel muscarinic receptor agonist, SNI-2011 ((+/-)-cis-2-methylspiro[1,3-oxathiolane-5,3'-quinuclidine] monohydrochloride hemihydrate, cevimeline, CAS 153504-70-2), is a candidate therapeutic drug for xerostomia in Sjögren's syndrome. The general pharmacological properties of this drug on the gastrointestinal, urinary and reproductive systems and other(More)
BACKGROUND Monocrotaline is a hepatotoxic agent which exerts predominant toxicity to central veins and centrilobular sinusoids. In this study, we investigated the effects of deleted variant of hepatocyte growth factor (dHGF) on monocrotaline-induced hepatic injury in rats. METHODS 100 mg/kg monocrotaline was gavaged to male rats twice with a 4-days'(More)
In this paper, we report the progress in developing a silica-aerogel-based cosmic dust capture panel for use in the Tanpopo experiment on the International Space Station (ISS). Previous studies revealed that ultralow-density silica aerogel tiles, comprising two layers with densities of 0.01 and 0.03 g/cm3 developed using our production technique, were(More)
We prepared thermal heterocopolymers of amino acids, aspartic acid and proline, and solubilized them in distilled water at boiling temperature. The resulting suspension was then cooled down while controlling the cooling rate. The maximum growth of phase-separated microspheres was found to occur at a finite, nonzero cooling rate. Temperature-gradient(More)
Solid microspheres, that were phase-separated in aqueous suspensions of thermal heterocomplex molecules made by heating a mixture of amino adds, transformed into husk-like microcapsules as pH increased. The transformation from solid microspheres into microcapsules proceeded at two different time scales. Rapid dissolution of thermal heterocomplex molecules(More)
We tested the stability and reaction of several amino acids using hydrothermal system simulators: an autoclave and two kinds of flow reactors at 200–250 °C. This study generally showed that there is a variation in the individual amino acids survivability in the simulators. This is mainly attributed to the following factors; heat time, cold quenching(More)
The surface of a microspherical structure formed in the aqueous suspension of thermal heterocomplex molecules made by heating aspartic acid and proline can adsorb basic amino acids such as histidine, lysine and arginine. It can also adsorb adenine, cytosine, adenosine and cytidine. Electrostatic interactions acting between those monomers to be adsorbed and(More)
A novel muscarinic receptor agonist, SNI-2011 ((+/-)-cis-2-methylspiro[1,3-oxathiolane-5,3'-quinuclidine] monohydrochloride hemihydrate, cevimeline, CAS 153504-70-2), is a candidate therapeutic drug for xerostomia in Sjögren's syndrome. The general pharmacological properties of this drug on general behavior and the central nervous system were investigated(More)
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