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1. The purpose of this study was to evaluate the mechanical response to stretch in normal human ankle dorsiflexors at different levels of voluntary contraction. In an active muscle, the total mechanical response is the sum of the intrinsic response from the contractile apparatus, the response from passive tissues, and the reflex mediated response. Each of(More)
1. During maintained ankle extension with background torques ranging from 0 to 70 N.m, the ankle extensors were stretched by a 5 degree rotation of the ankle joint. Maximal stretch velocity was 170 degrees/s. Regression analysis of simultaneous measurements of total torque and needle and surface electromyograms (EMG) from the soleus and gastrocnemius(More)
In this study, we have measured the passive, the intrinsic, and the reflex-mediated mechanical response to stretch of the ankle extensors and flexors in 13 spastic multiple sclerosis patients and 10 healthy control subjects. In the ankle flexors, the patients had no reflex-mediated stiffness. The passive stiffness was increased by 138% (95% confidence(More)
BACKGROUND The present study assessed the efficacy and safety of vernakalant hydrochloride (RSD1235), a novel compound, for the conversion of atrial fibrillation (AF). METHODS AND RESULTS Patients were randomized in a 2:1 ratio to receive vernakalant or placebo and were stratified by AF duration of 3 hours to 7 days (short duration) and 8 to 45 days (long(More)
The objective of the present study was to assess the safety and effectiveness of vernakalant hydrochloride injection (RSD1235), a novel antiarrhythmic drug, for the conversion of atrial fibrillation (AF) or atrial flutter to sinus rhythm (SR). Patients with either AF or atrial flutter were randomized in a 1:1 ratio to receive vernakalant (n = 138) or(More)
Digital stethoscopes offer new opportunities for computerized analysis of heart sounds. Segmentation of heart sound recordings into periods related to the first and second heart sound (S1 and S2) is fundamental in the analysis process. However, segmentation of heart sounds recorded with handheld stethoscopes in clinical environments is often complicated by(More)
The EMG response and the mechanical response to 2 degree stretch of the human anterior tibial muscle was studied during contractions ranging from 0% to 80% of maximal voluntary contraction (MVC). The EMG response showed three distinct peaks M1, M2, and M3 with peak latencies of 59 ms, 86 ms, and 120 ms respectively. At low background torques M1 dominated(More)
The thin afferent nerves were tested quantitatively by determining the thresholds of warmth and pricking pain to argon laser stimulation and by measuring the brain potentials related to pricking pain. In 27 patients with electrophysiologically verified carpal tunnel syndrome these parameters were measured from fingers 3 and 5 on both hands. All patients had(More)
Objective.Clinical measurements of pulmonary gas exchangeabnormalities might help prevent hypoxaemia and be useful in monitoringthe effects of therapy. In clinical practice single parameters are oftenused to describe the abnormality e.g., the “effectiveshunt.” A single parameter description is often insufficient,lumping the effects of several abnormalities.(More)
BACKGROUND Dietary n-3 polyunsaturated fatty acids (PUFAs) derived from fish may reduce the incidence of sudden cardiac death (SCD). In addition, wine drinking is suggested to have a protective effect against cardiovascular death. METHODS AND RESULTS We included 291 patients referred for coronary angiography in whom ischemic heart disease was suspected(More)