Efstratios N. Pistikopoulos

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For discrete-time linear time invariant systems with constraints on inputs and states, we develop an algorithm to determine explicitly, the state feedback control law which minimizes a quadratic performance criterion. We show that the control law is piece-wise linear and continuous for both the "nite horizon problem (model predictive control) and the usual(More)
Control based on on-line optimization, popularly known as model predictive control (MPC), has long been recognized as the winning alternative for constrained sys t ems . The main limitation of MPC is, however, its on-line computat ional complexity. For discrete-time linear time-invariant systems with constraints on inputs and states, we develop an algorithm(More)
Optimal delivery of chemotherapeutic agents in cancer Pinky Dua a,1, Vivek Dua b, Efstratios N. Pistikopoulos a,∗ a Centre for Process Systems Engineering, Department of Chemical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom b Centre for Process Systems Engineering, Department of Chemical Engineering,(More)
Corrigendum Corrigendum to: “The explicit linear quadratic regulator for constrained systems” [Automatica 38(1) (2002) 3–20] Alberto Bemporada ;∗, Manfred Morarib, Vivek Duac, Efstratios N. Pistikopoulosc aDipartimento di Ingegneria dell’Informazione, Universit a di Siena, Via Roma 56, 53100 Siena, Italy bInstitut f! ur Automatik, ETH Swiss Federal(More)
In this paper, we present a novel mixed integer nonlinear (MINLP) model for the daily well scheduling in petroleum fields, where the nonlinear reservoir behaviour, the multiphase flow in wells and constraints from the surface facilities are simultaneously considered. Discrete decisions include the operational status of wells (open or closed), the allocation(More)
A general class of branch and bound algorithms for solving a wide class of nonlinear programs with branching only in a subset of the problem variables is presented. By reducing the dimension of the search space, this technique may dramatically reduce the number of iterations and time required for convergence to tolerance while retaining proven exact(More)
This paper is one outcome of my very productive collaboration with Stratos Pistikopoulos while we were both at Imperial College London. It presents an attempt to take a truly integrated approach to the design of a process and its control system. Based on an optimisation framework, the paper illustrates the complexities involved in implementing a fully(More)
For people with type 1 diabetes, automatic controllers aim to maintain the blood glucose concentration within the desired range of 60–120 mg/dL by infusing the appropriate amount of insulin in the presence of meal and exercise disturbances. Blood glucose concentration outside the desired range can be harmful to an individual’s health but concentration below(More)