Edwin T Swarbrick

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BACKGROUND The number of patients with chronic gastrointestinal (GI) symptoms after cancer therapies which have a moderate or severe impact on quality of life is similar to the number diagnosed with inflammatory bowel disease annually. However, in contrast to patients with inflammatory bowel disease, most of these patients are not referred for(More)
AIM To study the availability and quality of adult and paediatric colonoscopy in three National Health Service (NHS) regions. METHOD A prospective four month study of colonoscopies in North East Thames, West Midlands, and East Anglia. PATIENTS Subjects undergoing colonoscopy in 68 endoscopy units. RESULTS A total of 9223 colonoscopies were studied.(More)
OBJECTIVE To determine whether azathioprine can prevent relapse in ulcerative colitis. DESIGN One year placebo controlled double blind trial of withdrawal or continuation of azathioprine. SETTING Outpatient clinics of five hospitals. SUBJECTS 79 patients with ulcerative colitis who had been taking azathioprine for six months or more. Patients in full(More)
trogen on risk of coronary heart disease is small relative to other risk factors then any effect of the menopause may be masked. Witteman et al argue that age related trends in coronary heart disease mortality are not inconsistent with an effect of the menopause. They used simulation models based on levels of risk of coronary heart disease in men to(More)
Germline mutations or large-scale deletions in the coding region and splice sites of STK11/LKB1 do not account for all cases of Peutz-Jeghers syndrome (PJS). It is conceivable that, on the basis of data from other diseases, inherited variation in promoter elements of STK11/LKB1 may cause PJS. Phylogenetic foot printing and transcription factor binding site(More)
To test the hypothesis that Crohn's disease is caused by delayed exposure to enteric infections, we did a case-control study. We compared 133 patients who have Crohn's disease and 231 with ulcerative colitis who have controls selected from the general population and matched for age and sex. Crohn's disease was more common in subjects whose first houses had(More)
BACKGROUND Despite widespread use of aminosalicylates as maintenance treatment for ulcerative colitis (UC), patients still report troublesome symptoms, often nocturnally. AIM To compare the efficacy and safety of balsalazide (Colazide) with mesalazine (Asacol) in maintaining UC remission. METHODS A randomized, double-blind comparison of balsalazide 3 g(More)
Germline mutations in the LKB1/STK11 tumour suppressor gene cause Peutz–Jeghers syndrome (PJS), a rare dominant disorder. In addition to typical hamartomatous gastrointestinal polyps and pigmented perioral lesions, PJS is associated with an increased risk of tumours at multiple sites. Follow-up information on carriers is limited and genetic heterogeneity(More)
Among fifty-seven patients with proven coeliac disease three also had thyrotoxicosis, two insulin dependant diabetes, three fibrosing alveolitis and one each had vitiligo, rheumatoid arthritis and cryptogenic cirrhosis. Autoantibodies were demonstrated in twelve of thirty-one patients tested, seven of these twelve had one of the above associated conditions.(More)
OBJECTIVE To determine the efficacy of lansoprazole 30 mg given in the morning compared with high-dose ranitidine 300 mg twice daily in the treatment of patients with oesophageal strictures. DESIGN A multicentre, outpatient, double-blind, parallel group, prospectively randomized clinical trial. PATIENTS One hundred and fifty-eight patients (lansoprazole(More)