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Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia.

• Joseph L Goldstein, Helmut G. Schrott, William R. Hazzard, Edwin L. Bierman, Arno G. Motulsky
• The Journal of clinical investigation
• 1973

To assess the genetics of hyperlipidemia in coronary heart disease, family studies were carried out in 2520 relatives and spouses of 176 survivors of myocardial infarction, including 149… (More)

Evidence for a common, saturable, triglyceride removal mechanism for chylomicrons and very low density lipoproteins in man.

• John D. Brunzell, William R. Hazzard, Daniel Porte, Edwin L. Bierman
• The Journal of clinical investigation
• 1973

Hypertriglyceridemic subjects were fed diets in which dietary fat calories were held constant, but carbohydrate calories were varied. Three subjects with fasting chylomicronemia (Type V) were given… (More)

Modification of low density lipoprotein by lipoprotein lipase or hepatic lipase induces enhanced uptake and cholesterol accumulation in cells.

• Michael Y Aviram, Edwin L. Bierman, Alan Chait
• The Journal of biological chemistry
• 1988

Incubation of low density lipoprotein(s) (LDL) with either lipoprotein lipase or hepatic lipase led to modification of the core lipid composition of LDL. Both lipases modified LDL by substantially… (More)

Protein kinase C as a mediator of high density lipoprotein receptor-dependent efflux of intracellular cholesterol.

• Armando Mendez, John F. Oram, Edwin L. Bierman
• The Journal of biological chemistry
• 1991

The interaction of high density lipoproteins (HDL) with the HDL receptor stimulates the translocation of cholesterol from intracellular pools to the plasma membrane where the cholesterol becomes… (More)

Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction.

• Joseph L Goldstein, William R. Hazzard, Helmut G. Schrott, Edwin L. Bierman, Arno G. Motulsky
• The Journal of clinical investigation
• 1973

Plasma cholesterol and triglyceride levels were measured after an overnight fast in 500 consecutively studied 3-mo survivors of myocardial infarction. Virtually all patients under 60 yr of age (95%… (More)

Hypertriglyceridemia. A metabolic consequence of chronic renal failure.

• John D Bagdade, Daniel Porte, Edwin L. Bierman
• The New England journal of medicine
• 1968

Depletion of plasma-membrane sphingomyelin rapidly alters the distribution of cholesterol between plasma membranes and intracellular cholesterol pools in cultured fibroblasts.

• J Peter Slotte, Edwin L. Bierman
• The Biochemical journal
• 1988

This study examines the relationship between cellular sphingomyelin content and the distribution of unesterified cholesterol between the plasma-membrane pool and the putative intracellular regulatory… (More)

Fatty streak expansion and maturation in Watanabe Heritable Hyperlipemic and comparably hypercholesterolemic fat-fed rabbits.

• Michael E Rosenfeld, Takehiro Tsukada, Alan Chait, Edwin L. Bierman, Allen M. Gown, Russell R. Ross
• Arteriosclerosis
• 1987

This study focuses on the expansion and maturation of the fatty streak in the aorta of Watanabe Heritable Hyperlipemic rabbits and comparably hypercholesterolemic fat-fed rabbits between 2 and 6… (More)

The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects.

• John D Bagdade, Edwin L. Bierman, Daniel Porte
• The Journal of clinical investigation
• 1967

The level of insulin after an overnight fast (basal) in 37 obese and nonobese male subjects with normal and abnormal carbohydrate tolerance was directly related to the increase in insulin… (More)

Nonenzymatic glycosylation of HDL resulting in inhibition of high-affinity binding to cultured human fibroblasts.

• P. Barton Duell, John F. Oram, Edwin L. Bierman
• Diabetes
• 1990

Nonenzymatic glycosylation of plasma proteins may contribute to the excess risk of developing atherosclerosis in patients with diabetes mellitus. Because high-density lipoprotein (HDL) is believed to… (More)

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