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Previous research on stroke rehabilitation has not established whether increase in physical therapy lead to better intrinsic recovery from hemiplegia. A detailed study was carried out of recovery of arm function after acute stroke, and compares orthodox physiotherapy with an enhanced therapy regime which increased the amount of treatment as well as using(More)
This study aimed to determine whether the decline of the analgesic effect of morphine with a continuous infusion or that after a single injection correlates with the changes in brain concentration of morphine. The analgesic effect of morphine and its brain and serum concentrations were determined with a continuous 8-h infusion at a constant rate and after a(More)
UNLABELLED Ketamine administered intraoperatively in very small doses reduces postoperative opioid consumption. We suggest that this effect is the result of attenuation of acute tolerance to the analgesic effect of opioids. We sought to demonstrate that acute tolerance induced by alfentanil infusion can be attenuated by a dose of ketamine that is too small(More)
BACKGROUND The vanilloid receptors (TRPV1) are found in peripheral nerve fibers; their stimulation by capsaicin leads to release of calcitonin gene-related peptide and other neuropeptides participating in neuroinflammation. On the other hand, various inflammatory mediators, released after nerve damage, can activate or sensitize the TRPV1 receptors. These(More)
It was found that the surname-based representation of Jewish authors in the top US biomedical journals corresponds to the representation of Jewish Nobel Laureates in Medicine among US laureates: Both of them are almost equally disproportionately high, with the ratio of actual to expected number close to 20 (Kissin, Scientometrics 89:273–280, 2011). The main(More)
To assess the probability of success of an analgesic drug we have proposed a bibliometric indicator, the Top Journals Selectivity Index (TJSI) (Kissin 2011). It represents the ratio (as %) between the number of all types of articles on a particular drug in the top 20 biomedical journals and the number of articles on that drug in all (>5,000) journals(More)
BACKGROUND Recent evidence suggests that the duration of the nociceptive block may be an important factor in determining the effect of the block on injury-induced hyperalgesia after block resolution. The authors examined whether a tonicaine nerve block lasting for 12 to 16 h could prevent late inflammatory hyperalgesia. METHODS Inflammatory hyperalgesia(More)
In rat experiments, morphine-pentobarbital antinociceptive interaction affecting cardiac acceleration in response to somatic noxious stimulation was analyzed with the use of intrathecal and intracerebroventricular injections of morphine. Cardiac acceleration response was induced by tail compression, and heart rate was monitored by electrocardiogram.(More)
Experimental data in humans and animals suggest that during surgery, pain impulses enter the CNS creating a hyperexcitable state in spite of general anesthesia. In a prospective double blind study, pain levels in 22 children undergoing tonsillectomy and adenoidectomy under general anesthesia were compared from day of surgery to Day 10. Patients received(More)