Escherichia coli O157:H7 infection in Dutch belted and New Zealand white rabbits.
- A. Panda, I. Tatarov, L. Detolla
- Medicine, BiologyComparative medicine
- 1 February 2010
Evidence is provided that both breeds of rabbits are susceptible to E. coli O157:H7 infection and that both may be useful models for investigating EHEC infections of humans, and both breeds developed clinical signs of disease and intestinal lesions after experimental infection.
In Vivo Performance of a Novel Fluorinated Magnetic Resonance Imaging Agent for Functional Analysis of Bile Acid Transport
- Diana Vivian, Kunrong Cheng, J. Polli
- Biology, ChemistryMolecular Pharmaceutics
- 7 April 2014
This represents the first report of in vivo imaging of an orally absorbed drug using 19F MRI, and gallbladder bile CA-lys-TFA levels were 30-fold lower compared to WT animals.
A challenge model for Shigella dysenteriae 1 in cynomolgus monkeys (Macaca fascicularis).
- S. Shipley, A. Panda, L. Detolla
- Medicine, BiologyComparative medicine
- 1 February 2010
A reliable challenge model of infection with wild-type S. Dysenteriae 1 in cynomolgus macaques is developed that reproducibly induces disease and elicits robust immune responses and may provide unique insights into the immunologic mechanisms of protection to S. dysenteriai 1 in advancing development of a vaccine against shigellosis.
Improved Tolerability of a Salmonella enterica Serovar Typhimurium Live-Attenuated Vaccine Strain Achieved by Balancing Inflammatory Potential with Immunogenicity
- E. Higginson, G. Ramachandran, S. Tennant
- BiologyInfection and Immunity
- 24 September 2018
New vaccine strain CVD 1926 (I77 ΔguaBA ΔclpP ΔpipA ΔhtrA) was assessed for inflammatory potential in an organoid model of human intestinal mucosa, where it induced less inflammatory cytokine production than organoids exposed to the precursor vaccine, CVD 1921.
Intermittent inappetence and fur loss in a New Zealand White rabbit
- K. Kolappaswamy, Edwin H. Kriel, C. Mcleod, L. Detolla
- Medicine, BiologyLab animal
- 1 April 2006
A two-year-old, male New Zealand White (NZW) rabbit was presented to the clinical veterinarian for inappetence and fur loss and it was decided to euthanize the rabbit due to the continued inAppetance and slow deterioration while receiving clinical therapy.
Case Study Mycobacterium kansasii Isolated from Tuberculin-positive Rhesus Macaques ( Macaca mulatta ) in the Absence of Disease
- S. Shipley, David K. Johnson, L. Detolla
- Biology, Medicine
- 2017
6 Chinese-origin rhesus macaques infected with Mycobacterium kansasii that exhibited positive tuberculin skin tests in the absence of disease raises serious concerns regarding diagnostic methods used for infected NHP.
Su2017 In Vivo Performance of a Novel Fluorinated Magnetic Resonance Imaging Agent for Functional Analysis of Bile Acid Transport
- Diana Vivian, Kunrong Cheng, J. Polli
- Biology
- 1 May 2014
Mycobacterium kansasii Isolated from Tuberculinpositive Rhesus Macaques (Macaca mulatta) in the Absence of Disease.
- S. Shipley, David K. Johnson, L. Detolla
- Biology, MedicineComparative medicine
- 2017
Six Chinese-origin rhesus macaques infected with Mycobacterium kansasii that exhibited positive tuberculin skin tests in the absence of disease raises serious concerns regarding diagnostic methods used for infected NHP.