• Publications
  • Influence
Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
Expression of the human telomerase catalytic component, hTERT, in normal human somatic cells can reconstitute telomerase activity and extend their replicative lifespan. We report here that at twiceExpand
  • 644
  • 15
IFATS Collection: Adipose Stromal Cells Adopt a Proangiogenic Phenotype Under the Influence of Hypoxia
Evolving evidence suggests a possible role for adipose stromal cells (ASCs) in adult neovascularization, although the specific cues that stimulate their angiogenic behavior are poorly understood. WeExpand
  • 129
  • 5
Endothelial progenitor cells participate in nicotine-mediated angiogenesis.
OBJECTIVES We aimed to determine the role of endothelial progenitor cells (EPCs) in cholinergic angiogenesis. BACKGROUND Recently, we provided evidence for a new angiogenic pathway mediated byExpand
  • 82
  • 4
  • Open Access
The Exosome Total Isolation Chip.
Circulating tumor-derived extracellular vesicles (EVs) have emerged as a promising source for identifying cancer biomarkers for early cancer detection. However, the clinical utility of EVs has thusExpand
  • 63
  • 3
A Central Role for Nicotinic Cholinergic Regulation of Growth Factor–Induced Endothelial Cell Migration
  • M. Ng, J. Wu, +4 authors J. Cooke
  • Medicine, Biology
  • Arteriosclerosis, thrombosis, and vascular…
  • 1 January 2007
Objective—An endothelial nicotinic acetylcholine receptor (nAChR) participates in atherogenesis and tumorigenesis by promoting neovascularization. To date, the mechanisms of nAChR-mediatedExpand
  • 77
  • 1
PET imaging of tumor glycolysis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2
A PET imaging reagent targeting PKM2 allows noninvasive assessment of glycolysis in glioblastoma multiforme, distinguishing it from normal brain tissue. A new view of brain tumors Tumor cells areExpand
  • 29
  • 1
  • Open Access
Exercise Induces Stromal Cell–Derived Factor-1&agr;–Mediated Release of Endothelial Progenitor Cells with Increased Vasculogenic Function
Background: Endothelial progenitor cells have been shown to traffic to and incorporate into ischemic tissues, where they participate in new blood vessel formation, a process termed vasculogenesis.Expand
  • 22
  • 1
AshwaMAX and Withaferin A inhibits gliomas in cellular and murine orthotopic models
Abstract Glioblastoma multiforme (GBM) is an aggressive, malignant cancer Johnson and O’Neill (J Neurooncol 107: 359–364, 2012). An extract from the winter cherry plant (Withania somnifera),Expand
  • 17
  • 1
Intranasal delivery of targeted polyfunctional gold-iron oxide nanoparticles loaded with therapeutic microRNAs for combined theranostic multimodality imaging and presensitization of glioblastoma to
The prognosis for glioblastoma (GBM) remains depressingly low. The biological barriers of the brain present a major challenge to achieving adequate drug concentrations for GBM therapy. To addressExpand
  • 10
  • 1
A Novel Theranostic Strategy for MMP-14–Expressing Glioblastomas Impacts Survival
Glioblastoma (GBM) has a dismal prognosis. Evidence from preclinical tumor models and human trials indicates the role of GBM-initiating cells (GIC) in GBM drug resistance. Here, we propose a newExpand
  • 18