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Microelectrode arrays (MEAs) are designed to monitor and/or stimulate extracellularly neuronal activity. However, the biomechanical and structural mismatch between current MEAs and neural tissues remains a challenge for neural interfaces. This article describes a material strategy to prepare neural electrodes with improved mechanical compliance that relies(More)
Neural interfaces are implanted devices that couple the nervous system to electronic circuitry. They are intended for long term use to control assistive technologies such as muscle stimulators or prosthetics that compensate for loss of function due to injury. Here we present a novel design of interface for peripheral nerves. Recording from axons is(More)
We have demonstrated that micro-channel electrode arrays with 100 microm x 100 microm cross-section channels support axon regeneration well, and that micro-channels of similar calibre and up to 5 mm long can support axon regeneration and vascularisation. They may be microfabricated using silicon, silicone, or polyimide and thin metal films to form 3-D(More)
Assessment of heart function in zebrafish larvae using electrocardiography (ECG) is a potentially useful tool in developing cardiac treatments and the assessment of drug therapies. In order to better understand how a measured ECG waveform is related to the structure of the heart, its position within the larva and the position of the electrodes, a 3D model(More)
The spiral peripheral nerve interface (SPNI) has been developed to record neural activity by utilizing the body's own ability to regenerate axons after injury. The implantable device is capable of providing a chronic recording array for use with technology designed to compensate for a loss of motor function. The SPNI offers a good route to establishing an(More)
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