Edward Seclaman

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Polyhydroxylated chalcones are able to efficiently inhibit aldose reductase (ALR2; EC, an enzyme implicated in the development of diabetic complications. In this study, we performed docking experiments on a series of 38 2′-hydroxy and 2′,4′-dihydroxychalcones with measured inhibitory activities. We demonstrate that docking the chalcones into a(More)
Docking studies have become popular approaches in drug design, where the binding energy of the ligand in the active site of the protein is estimated by a scoring function. Many promising techniques were developed to enhance the performance of scoring functions including the fusion of multiple scoring functions outcomes into a so-called consensus scoring(More)
The present study focuses on the application of a therapeutic strategy in patients with chronic severe lower limb ischaemia using a plasmid vector encoding the vascular endothelial growth factor (phVEGF(165)). It has been shown that VEGF promotes neo-vascularization and blood vessel network formation and thus might have the ability to improve blood-flow at(More)
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