Edward L Merrin

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Coherence analysis of the EEG is used to study the coupling between cortical regions. High coherence between signals recorded at 2 electrodes is interpreted as evidence for neuroanatomic connections between the cortical areas underlying the electrodes. When common reference recordings are used, coherence measures the relationship between 2 time series, each(More)
  • E L Merrin
  • The British journal of psychiatry : the journal…
  • 1984
The relationship was examined between sinistral eye and hand preference and age at first hospitalisation, clinical course and social competence in chronic schizophrenics. Motor and sighting dominance were assessed in 52 newly admitted chronic schizophrenic males. Left-handedness in this study was associated with inferior social competence, but left-eyedness(More)
The authors studied the scalp topography of P300 responses to novel auditory stimuli and its relationship to negative symptoms in medication-free hospitalized schizophrenic patients. Schizophrenics (n = 12), patients with major mood disorders (n = 13), and 17 non-ill controls (all men) responded to rare target tones while ignoring background tones and rare(More)
In vivo 31Phosphorous magnetic resonance spectroscopic imaging (31P MRSI) was performed on 18 chronic schizophrenic patients and 14 normal controls to determine if there was asymmetry of high-energy phosphorous metabolism in the temporal lobes of schizophrenic patients. Temporal lobe phosphorous metabolites were also correlated with severity of psychiatric(More)
The relationship between frontal lobe phospholipid measures as measured by in vivo 31phosphorus magnetic resonance spectroscopic imaging and performance on the Wisconsin Card Sort Test was examined in 16 chronic schizophrenic patients and 13 normal controls. Lower left frontal phosphomonoester levels in the schizophrenics were associated with fewer(More)
Studies to determine the validity of the Mini-Mental State Examination (MMSE) and the Cognitive Capacity Screening Examination (CCSE) have indicated unacceptably high false-negative rates for these tests. To determine whether a new examination, the Neurobehavioral Cognitive Status Examination (NCSE), is more sensitive in the detection of cognitive(More)
The authors previously reported that negative symptoms were associated with reduced EEG alpha power and coherence in medication-free schizophrenic inpatients. These post-hoc findings were based on resting EEG data in an eyes open condition. This report describes the replication of these results in a new sample of 17 male veterans (aged 38 +/- 8) recently(More)
In vivo 31Phosphorus magnetic resonance spectroscopic imaging (31P MRSI) was performed on 20 chronic schizophrenic patients and 16 normal controls to determine if there were specific changes in high energy phosphorus and phospholipid metabolism in the frontal lobes of schizophrenic patients. Phosphorous metabolites were assessed in each of the left and(More)
Quantitative analyses of electroencephalographic (EEG) recordings in schizophrenic patients have often demonstrated reduced alpha band (8-13 Hz) activity. However, this finding is not universal and there is some evidence that subgroups of schizophrenics may differ in overall or lateralized levels of EEG alpha activity. To investigate this issue, the authors(More)
OBJECTIVE The authors examined whether there are abnormalities in high-energy phosphorous metabolism in the basal ganglia of schizophrenic patients. METHOD In vivo 31P magnetic resonance spectroscopic imaging was performed on 18 chronic schizophrenic patients and 16 healthy comparison subjects. The percentages of total phosphorous signal for(More)