Edward Kisak

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Assembling structures to divide space controllably and spontaneously into subunits at the nanometer scale is a significant challenge, although one that biology has solved in two distinct ways: prokaryotes and eukaryotes. Prokaryotes have a single compartment delimited by one or more lipid-protein membranes. Eukaryotes have nested-membrane structures that(More)
Colloidal aggregation can be made self-limiting by controlling the ratio of reactive groups (ligands such as biotin coupled to phospholipids and incorporated in a vesicle membrane) on the colloid surface to crosslinking agents (multifunctional receptors such as avidin or streptavidin) in solution. A distinct transition occurs between limited and complete(More)
Chemical permeation enhancers can permeabilize the human skin to enable transdermal delivery of drugs, but their use is often limited by the accompanying skin irritation. Novel chemical enhancer combinations based on synergistic interactions amongst their components have the potential to address this limitation. However, discovery of such combinations(More)
It has been demonstrated recently1,2 that phospholipid vesicles are inherently less robust than vesicles formed of thicker bilayered block copolymers and, therefore, that block copolymer vesicles may prove more useful for encapsulation technologies. Vesicles can be formed from block copolymers with hydrophobic blocks of poly(ethylethylene), polybutadiene,(More)
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