Edward K. S. Ong

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BACKGROUND Chikungunya virus (CHIKV) infection induces arthralgia. The involvement of inflammatory cytokines and chemokines has been suggested, but very little is known about their secretion profile in CHIKV-infected patients. METHODS A case-control longitudinal study was performed that involved 30 adult patients with laboratory-confirmed Chikungunya(More)
Chikungunya virus (CHIKV) is an alphavirus that causes chronic and incapacitating arthralgia in humans. To date, interactions between the immune system and the different stages of the virus life cycle remain poorly defined. We demonstrated for the first time that CHIKV Ags could be detected in vivo in the monocytes of acutely infected patients. Using in(More)
BACKGROUND Chikungunya virus (CHIKV) and related arboviruses have been responsible for large epidemic outbreaks with serious economic and social impact. Although infected individuals clear the virus from the blood, some develop debilitating and prolonged arthralgia. METHODS We investigated specificity and strength of antibody responses in a longitudinal(More)
The re-emergence of Chikungunya fever, an old tropical infectious disease with new characteristics represents a major public health problem with severe social and economic burdens globally. Though Chikungunya has previously been known as a relatively benign disease, its recent re-emergence has caused considerable morbidity with even some cases of fatality.(More)
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