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- Kaleb M. Pauley, Minoru Satoh, Annie L C Chan, Michael R. Bubb, Westley H. Reeves, Edward K L Chan
- Arthritis research & therapy
- 2008
INTRODUCTION
MicroRNAs are small noncoding RNA molecules that negatively regulate gene expression via degradation or translational repression of their targeted mRNAs. It is known that aberrant… (More)
- Md A. Nahid, Kaleb M. Pauley, Minoru Satoh, Edward K L Chan
- The Journal of biological chemistry
- 2009
The human toll-like receptor 4 (TLR4) pathway is activated in response to lipopolysaccharide (LPS), and subsequent signal transductions lead to the production of cytokines such as tumor necrosis… (More)
- Md A. Nahid, Minoru Satoh, Edward K L Chan
- Journal of immunology
- 2011
Human TLRs are critical sensors for microbial components leading to the production of proinflammatory cytokines that are controlled by various mechanisms. Monocytes pretreated with LPS exhibit a… (More)
- Karen Meerovitch, Yuri V. Svitkin, +6 authors Nahum Sonenberg
- Journal of virology
- 1993
Translation initiation on poliovirus RNA occurs by internal binding of ribosomes to a sequence within the 5' untranslated region. We have previously characterized a HeLa cell protein, p52, that binds… (More)
- Edward K L Chan, Jan Damoiseaux, +10 authors L E Coelho Andrade
- Front. Immunol.
- 2015
During the 12th International Workshop on Autoantibodies and Autoimmunity held in Sao Paulo, Brazil, on August 28, 2014, a full day session was devoted to establishing a consensus on the nomenclature… (More)
- Linda Soo Hoo, Jianying Zhang, Edward K L Chan
- Oncogene
- 2002
Recently our laboratory identified a cytoplasmic RNA-binding protein p62 which binds to and regulates the expression of IGF II mRNA. p62 was initially shown to be recognized by auto-antibodies in… (More)
- Md A. Nahid, Minoru Satoh, Edward K L Chan
- Cellular and Molecular Immunology
- 2011
Toll-like receptors (TLRs) in innate immune cells are the prime cellular sensors for microbial components. TLR activation leads to the production of proinflammatory mediators and thus TLR signaling… (More)
- Minoru Satoh, Edward K L Chan, +5 authors Westley H. Reeves
- Expert review of clinical immunology
- 2007
Autoantibodies have been used extensively as a useful biomarker in systemic lupus erythematosus and other autoimmune rheumatic diseases. Antinuclear antibodies by immunofluorescence are a standard… (More)
- James A. Koziol, Jian-Ying Zhang, +5 authors Eng M Tan
- Clinical cancer research : an official journal of…
- 2003
PURPOSE AND EXPERIMENTAL DESIGN
Cancer sera contain antibodies which react with a unique group of autologous cellular antigens called tumor-associated antigens (TAAs), but the low frequency of… (More)
- C C Lung, Edward K L Chan, Bruce L Zuraw
- The Journal of allergy and clinical immunology
- 1997
The B2 bradykinin receptor (B2BKR) mediates most of the inflammatory actions of bradykinin. To evaluate its potential role in allergic diseases, we assessed the structure of the human B2BKR gene.… (More)