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Despite the increasing use of alternative techniques, endomyocardial biopsy remains the primary method for diagnosing cardiac allograft rejection. Improved patient longevity and an increasing number of transplantation centers are resulting in an increase in the number of biopsies performed. Although endomyocardial biopsy is usually considered a safe(More)
In this study the laminar localization of binding sites for the muscarinic radioligand [3H]3-quinuclidinylbenzilate was studied in somatosensory cortex of infant rat. Using light autoradiographic techniques, [3H]QNB was found to be concentrated in layer IV. Atropine-pretreated pups showed evenly dispersed, nonspecific binding in all layers. We conclude that(More)
BACKGROUND Prediction of prognosis remains a major unmet need in new-onset heart failure (HF). Although several clinical tests are in use, none accurately distinguish between patients with poor versus excellent survival. We hypothesized that a transcriptomic signature, generated from a single endomyocardial biopsy, could serve as a novel prognostic(More)
BACKGROUND Pulmonary hypertension is a clinically useful predictor of death in patients with heart failure. Whether pulmonary hypertension has the same prognostic value among specific underlying causes of cardiomyopathy is unknown. Using a diverse cohort of cardiomyopathy patients, we tested the hypotheses that (1) elevated mean pulmonary arterial pressure(More)
BACKGROUND Lymphocytic myocarditis is a clinically important condition that is difficult to diagnose and distinguish. We hypothesized that the transcriptome obtained from an endomyocardial biopsy would yield clinically relevant and accurate molecular signatures. METHODS AND RESULTS Microarray analysis was performed on samples from patients with(More)
OBJECTIVE To develop and prospectively evaluate a web-based tool that forecasts the daily bed need for admissions from the cardiac catheterization laboratory using routinely available clinical data within electronic medical records (EMRs). METHODS The forecast model was derived using a 13-month retrospective cohort of 6384 catheterization patients.(More)
  • About Ctre, Isu, +20 authors Joe Jurasic
  • 2007
versity is to develop and implement innovative methods, materials, and technologies for improv­ ing transportation efficiency, safety, and reliability while improving the learning environment of students, faculty, and staff in transportation-related fi elds. The contents of this report reflect the views of the authors, who are responsible for the facts and(More)