Edward J. Williams

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Single transgene copy, vector backbone-free transgenic crop plants are highly desired for functional genomics and many biotechnological applications. We demonstrate that binary vectors that use a replication origin derived from the Ri plasmid of Agrobacterium rhizogenes (oriRi) increase the frequency of single copy, backbone-free transgenic plants in(More)
When simulation analyses first became at least somewhat commonplace (as opposed to theoretical and research endeavors often considered esoteric or exploratory), simulation studies were usually not considered "projects" in the usual corporate-management context. When the evolution from "special research investigation" to "analytical project intended to(More)
Conventional Agrobacterium-mediated plant transformation often produces a significant frequency of transgenic events containing vector backbone sequence, which is generally undesirable for biotechnology applications. We tested methods to reduce the frequency of transgenic plants containing vector backbone by incorporating genes into the backbone that(More)
Chain conveyors are a specific type of conveyor often used in a variety of manufacturing and production applications, such as body and paint shops. These conveyors must typically interface with other types of conveyors such as cross-transfer conveyors, and also with other material-handling equipment such as lift tables and hold tables. Micromodeling of(More)
This study describes an application of discrete-process simulation to a final assembly process within the automotive industry. The study addressed the issues of whether the process design would meet production quotas, assessing the process flow times within the proposed system, verifying and improving the design of the conveyor system, and identifying and(More)
We describe the application of simulation analysis to a complex operational problem involving scheduling, sequencing, and material-handling decisions. The manufacturing process under study required close attention to correct mix and sequencing of raw materials, reduction of material-handling costs, high utilization of a resource having significant purchase(More)
This study details the synergistic application of ergonomic analysis, discrete-process simulation, and statistical analysis to the problems of determining the optimum design for a final engine drop assembly work station. The study comprised attention to analysis of facilities and tooling systems, material-handling systems, and ergonomic workplace design.(More)
As businesses and industries become steadily more global in their operational scope, and more intensely competitive, achievement of a lean, efficient, reliable supply chain increases in both importance and complexity. Recent research comprises many ideas to help engineers and managers construct and maintain such a supply chain. Additionally, numerous(More)
This paper describes a modular autonomous material handling equipment solution for flexible automation. Discrete Event Simulation is in this case used as a tool for shortening time spent in many different phases of manufacturing systems lifecycle. The paper presents the concept of autonomous modular material handling equipment, and how simulation is used as(More)