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A synergistic combination of two next-generation sequencing platforms with a detailed comparative BAC physical contig map provided a cost-effective assembly of the genome sequence of the domestic turkey (Meleagris gallopavo). Heterozygosity of the sequenced source genome allowed discovery of more than 600,000 high quality single nucleotide variants. Despite(More)
Expression of group III metabotropic glutamate receptors (mGluR) was established by RT-PCR and immunocytochemistry on a cultured clonal human neural stem/progenitor cell (hNSPC) line derived from fetal ventral mesencephalon (VM). Selective activation of these receptors by the group III mGluR agonist L-(+)-2-amino-4-phosphonobutyric acid (L-AP4) prevented(More)
Stroke remains one of the most promising targets for cell therapy. Thorough preclinical efficacy testing of human neural stem cell (hNSC) lines in a rat model of stroke (transient middle cerebral artery occlusion) is, however, required for translation into a clinical setting. Magnetic resonance imaging (MRI) here confirmed stroke damage and allowed the(More)
Huntington's disease (HD) is caused by the expansion of a CAG repeat in the huntingtin (HTT) gene. The R6/2 mouse model of HD expresses a mutant version of exon 1 HTT and develops motor and cognitive impairments, a widespread huntingtin (HTT) aggregate pathology and brain atrophy. Despite the vast number of studies that have been performed on this model,(More)
* Dartmouth's Greenpass project extends how public key cryptography can be used to secure the wireless LAN with a RADIUS (Remote Authentication Dial In User Service) server that is responsible for handling authentication requests from clients (called supplicants in the 802.1x authentication model). This thesis describes the design and implementation of the(More)
To validate and add value to non-invasive imaging techniques, the corresponding histology is required to establish biological correlates. We present an efficient, semi-automated image-processing pipeline that uses immunohistochemically stained sections to reconstruct a 3D brain volume from 2D histological images before registering these with the(More)
Huntington's disease (HD) is caused by the expansion of a CAG repeat in the huntingtin (HTT) gene. The R6 mouse models of HD express a mutant version of exon 1 HTT and typically develop motor and cognitive impairments, a widespread huntingtin (HTT) aggregate pathology and brain atrophy. Unlike the more commonly used R6/2 mouse line, R6/1 mice have fewer CAG(More)
The radial component of the solar magnetic field measured at Ulysses as it traveled from the equator in the southern hemisphere has been to-80.2 " latitude and returned. The radial component multiplied by the square of the radial distance, i.e., BRr2, averaged over 77 day intervals (three solar rotations) is approximately constant at-3.5 NT and shows no(More)
A study of the interplanetary sector structure at heliographic latitudes up to 16øN is reported. The study is based on magnetic field measurements made on board Pioneer 11 as the spacecraft traveled along the post-Jupiter-encounter trajectory. Preliminary measurements are used to determine the dominant polarity of the interplanetary magnetic field during 43(More)
The unique in situ observations acquired by the scientific instrumentation on board the Ulysses spacecraft have provided, for the first time, a comprehensive, 3-dimensional view of the heliosphere from the solar equator to the poles near solar minimum. Since beginning its journey out of the eclip-tic plane in February, 1992, Ulysses has acquired a wealth of(More)