Edward J. Coombes

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Age-standardised mortality-rates for a population of 2100 male workers exposed to vinyl chloride for periods of up to 27 years do not show any excess of total or cause-specific mortality. 1 case of angiosarcoma of the liver was identified just outside the study period. There was no suggestion of an increased frequency of deaths from the more common(More)
To ascertain the value of maternal serum free beta-human choriogonadotropin subunit measurement in Down's syndrome screening and to compare its effectiveness when screening with a variety of biochemical markers, we have evaluated maternal serum free beta-human choriogonadotropin, total human choriogonadotropin, alpha-fetoprotein and unconjugated oestriol in(More)
OBJECTIVE To determine the relation between maternal serum alpha fetoprotein and free beta human chorionic gonadotrophin concentrations in pregnancies complicated by trisomy 18 and establish whether prenatal biochemical screening for this condition could be developed in a way similar to that proposed for trisomy 21. DESIGN Serum alpha fetoprotein and free(More)
We report a multicentre clinical field trial of a novel dual analyte enzyme immunoassay method for the simultaneous measurement of alpha-fetoprotein (AFP) and free beta-human choriogonadotropin (hCG) in the same microtitre well. The assay was shown to have good technical performance in the hands of all trial centres, with between assay coefficients of(More)
We have developed an assay for alpha 2 macroglobulin in amniotic fluid, based on the technique of Fixed Time Kinetic Immunoturbidimetry. The assay is precise (CV 5% between assays) and has a detection limit of 0.4 mg/l. We have determined the reference range for alpha 2 macroglobulin from 100 amniotic fluid samples from none Neural Tube Defect pregnancies.(More)
Lipoprotein changes have been investigated in 16 patients with burn injury. Serum, urine, and blister fluid were examined for apoprotein content. In the group of patients with moderate burns serum High Density Lipoprotein (HDL) fell drastically, and Low Density Lipoprotein (LDL) decreased slightly, whilst Very Low Density Lipoprotein (VLDL) rose. In blister(More)
Thyroxine-binding prealbumin (TBPA) concentrations were measured in 54 patients with rheumatoid arthritis (RA) and 50 control subjects. TBPA levels were significantly depressed in the RA patients, of whom 15 had values below the laboratory reference range. Although significant negative correlations were seen between TBPA and the erythrocyte sedimentation(More)