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Simulation languages and the GUIs supporting them may be excellent tools for creating simulation codes, but are not necessarily the best tools to use for creating descriptions of systems, i. e., for modeling. In 2006, OMG published the initial standard specification (OMG 2006) for SysML (<u>Sys</u>tems <u>M</u>odeling(More)
We have used a sensitized ENU mutagenesis screen to produce mouse lines that carry mutations in genes required for epigenetic regulation. We call these lines Modifiers of murine metastable epialleles (Mommes). We report a basic molecular and phenotypic characterization for twenty of the Momme mouse lines, and in each case we also identify the causative(More)
Contemporary factories in capital intensive industries such as semiconductor manufacturing are very complex, with many sources of risk. The highly competitive and global business environment forces companies to analyze, design, and continuously redesign factories with distributed multidisciplinary teams. Traditional factory design approaches using(More)
Contemporary technology for Product Lifecycle Management (PLM) integrates computer aided design (CAD) and engineering analysis (CAE) to support rapid, distributed, team-oriented product data development and management, including high fidelity simulation on demand. This technology potentially provides a platform for creating a new generation of factory(More)
Simulation models of different fidelity levels are often available for a complex system. High-fidelity simulations are accurate but time-consuming. Therefore, they can only be applied to a small number of solutions. Low-fidelity simulations are faster and can evaluate a large number of solutions. But their results may contain significant bias and(More)
Observations of inherited phenotypes that cannot be explained solely through genetic inheritance are increasing. Evidence points to transmission of non-DNA molecules in the gamete as mediators of the phenotypes. However, in most cases it is unclear what the molecules are, with DNA methylation, chromatin proteins, and small RNAs being the most prominent(More)