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Alzheimer's disease (AD) is characterized by the deposition of amyloid-beta peptide (Abeta) and the formation of neurofibrillary tangles. Transplantation of bone marrow-derived mesenchymal stem cellsExpand
  • S L Schissel, George A. Keesler, Edward H Schuchman, Kevin Williams, Ira Tabas
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 1998 (First Publication: 17 July 1998)
  • The acid sphingomyelinase (ASM) gene, which has been implicated in ceramide-mediated cell signaling and atherogenesis, gives rise to both lysosomal SMase (L-SMase), which is reportedlyExpand
  • Calogera M. Simonaro, Robert J Desnick, Margaret M Mcgovern, Melissa P Wasserstein, Edward H Schuchman
  • Medicine, Biology
  • American journal of human genetics
  • 2002 (First Publication: 1 December 2002)
  • We have collected demographic and/or mutation information on a worldwide sample of 394 patients with type B Niemann-Pick disease (NPD). The disorder is panethnic, with the highest incidence occurringExpand