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Journals and Conferences
The circadian and neurobehavioral effects of light are primarily mediated by a retinal ganglion cell photoreceptor in the mammalian eye containing the photopigment melanopsin. Nine action spectrum studies using rodents, monkeys, and humans for these responses indicate peak sensitivities in the blue region of the visible spectrum ranging from 459 to 484 nm,… (More)
Light is being used as a pre-launch countermeasure to circadian and sleep disruption in astronauts. The effect of light on the circadian system is readily monitored by measurement of plasma melatonin. Our group has established an action spectrum for human melatonin regulation and determined the region of 446-477 nm to be the most potent for suppressing… (More)
Tamoxifen is a preferred agent for the treatment of breast cancer. While efficacious, it is not without serious side effects. Ocular toxicity to the cornea, retina, and optic nerve have been reported. We present a case of tamoxifen retinopathy and emphasize the need for periodic ophthalmologic examinations to prevent loss of vision.
The tonic pupil is generally defined as a pupil that is: (a) found usually in 20 to 40-year-old women, (b) unilateral in go per cent of cases, (c) larger than the uninvolved pupil in lighted surroundings and smaller in unlighted surroundings, (d) essentially unresponsive or sluggish to light and with a stronger reaction to near, (e) often associated with… (More)
A 31-year-old man with spastic paraparesis (diagnosed when he was 10 years old) and hyperglycinemia (diagnosed when he was 19 years old) had an intermittently swollen right eye and blurred vision. His right upper eyelid was S-shaped and edematous, the lateral canthal tendon was flaccid, and the eyelid everted easily. After the floppy eyelid syndrome was… (More)
A patient with a long history of alcohol abuse had diminished vision. The clinical and angiographic findings were consistent with Purtscher's retinopathy. Subsequently, the patient was hospitalized for acute pancreatitis. To our knowledge, this is the first reported case of pancreatic retinopathy preceding the systemic findings of acute pancreatitis.
Two cases of tonic pupil, hyporeflexia, and segmental hypohidrosis (Ross' syndrome) are reported. The relationship of this syndrome to other autonomic dysfunction is discussed. Those symptoms (emotional instability, loss of sweating, orthostatic hypotensive symptoms, and signs of bilaterality of the tonic pupil) which should alert the clinician to more… (More)