Edward G. Hayman

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In this paper, we demonstrate that a chondroitin sulfate proteoglycan purified from a rat yolk sac tumor alters the adhesion of the tumor cells to substrata containing fibronectin or type I collagen. In the presence of the proteoglycan, these substrata were much less adhesive and did not promote cell spreading. The inhibitory effect of the proteoglycan was(More)
E matrices are composed primarily of three types of macromolecules: collagens, proteoglycans, and glycoproteins. Collagens constitute a group of genetically distinct, but related, molecules with unique tissue distributions. Similarly, proteoglycans are a highly polymorphic group of molecules that also have specialized distributions in tissues and different(More)
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