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AIMS The aims of the study were, first, to critically evaluate lipoprotein(a) [Lp(a)] as a cardiovascular risk factor and, second, to advise on screening for elevated plasma Lp(a), on desirable levels, and on therapeutic strategies. METHODS AND RESULTS The robust and specific association between elevated Lp(a) levels and increased cardiovascular disease(More)
Even at low-density lipoprotein cholesterol (LDL-C) goal, patients with cardiometabolic abnormalities remain at high risk of cardiovascular events. This paper aims (i) to critically appraise evidence for elevated levels of triglyceride-rich lipoproteins (TRLs) and low levels of high-density lipoprotein cholesterol (HDL-C) as cardiovascular risk factors, and(More)
The treatment of Bell's palsy or idiopathic facial paralysis is highly controversial. Much of this contention surrounds the use of specific antiviral medication in this condition. The widely quoted Scottish Bell's Palsy Study 1 confirmed the efficacy of prednisolone in the recovery of facial function, but suggested that the antiviral acyclovir provided no(More)
Energy Technology Laboratory (NETL) researchers, in collaboration with investigators from industry, academia, and other national laboratories. The Journal will also feature articles written by invited experts in various fields of energy and environmental studies. NETL's programs assist in providing the United States with acceptable, affordable, and(More)
Conclusions Three commonly available face masks—a surgical mask, a pre-shaped mask, and a bandana—were challenged with saline aerosols in concentrations and particle size distributions representing dust storm conditions to determine their protective efficiencies. A N95 respirator was used as the positive control and challenged under the same conditions. All(More)
A therosclerosis arises in arteries as a chronic inflammatory response to hypercholesterolemia. Hypercholesterolemia leads to endothelial dysfunction in regions of disturbed arterial blood flow, causing adhesion of monocytes and their entry into the subendothelial space. In the subendothelium, monocytes differentiate into macrophages, take up oxidized or(More)
The requirement that medical treatment is 'evidence-based' has become an essential part of modern health-care practice. In the UK, the National Institute for Health and Clinical Excellence (NICE) has developed guidance to achieve national consensus on best practice. The role of NICE has often attracted controversy, particularly when expensive new treatments(More)