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Software watermarking is a tool used to combat software piracy by embedding identifying information into a program. Most existing proposals for software watermarking have the shortcoming that the mark can be destroyed via fairly straightforward semantics-preserving code transformations. This paper introduces path-based watermarking, a new approach to(More)
This paper presents an implementation of the novel water-marking method proposed by Venkatesan, Vazirani, and Sinha in their recent paper A Graph Theoretic Approach to Software Watermarking. An executable program is marked by the addition of code for which the topology of the control-flow graph encodes a watermark. We discuss issues that were identified(More)
In this paper, we discuss graph-theoretic approaches to software watermarking and fingerprinting. Software watermarking is used to discourage intellectual property theft and software fingerprinting is used to trace intellectual property copyright violations. We focus on two algorithms that encode information in software through the use of graph structures.(More)
This paper presents an implementation of the novel water-marking method proposed by Venkatesan, Vazirani, and Sinha in their recent paper A Graph Theoretic Approach to Software Watermarking. An executable program is marked by the addition of code for which the topology of the control-flow graph encodes a watermark. We discuss issues that were identified(More)
The 4.1 proteins are a family of multifunctional adaptor proteins. They promote the mechanical stability of plasma membranes by interaction with the cytoskeletal proteins spectrin and actin and are required for the cell surface expression of a number of transmembrane proteins. Protein 4.1R is expressed in heart and upregulated in deteriorating human heart(More)
The phosphoinositide 3-kinase/mammalian target of rapamycin/protein kinase B (PI3K/mTOR/Akt) signaling pathway is central to a plethora of cellular mechanisms in a wide variety of cells including leukocytes. Perturbation of this signaling cascade is implicated in inflammatory and autoimmune disorders as well as hematological malignancies. Proteins within(More)
Migration of naive CD4(+) T lymphocytes into lymphoid tissue is essential for their activation and subsequent roles in adaptive immunity. The adhesion molecule L-selectin (CD62L), critical for this process, is highly expressed on naive CD4(+) T lymphocytes and is downregulated upon T lymphocyte activation. We demonstrate protein expression of P2X7R on naive(More)
Glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) is part of a system of signals involved in controlling T-cell activation. Targeting and agonizing GITR in mice promotes antitumor immunity by enhancing the function of effector T cells and inhibiting regulatory T cells. Here, we describe MEDI1873, a novel hexameric human GITR(More)
QUALIFICATIONS OUTLINE  Professor of Biostatistics with more than 20 years' experience in biostatistics research, teaching and service in academics, pharmaceutical and biotech industries. Applied Meta-analysis using R (received Plaque of Honor for this short course)  Published more than 100 papers in biostatistics methodology and applications  Seven(More)