Edward A. Rietman

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Theoretical biology encompasses a broad range of biological disciplines ranging from mathematical biology and biomathematics to philosophy of biology. Adopting a broad definition of "biology", Theoretical Biology and Medical Modelling, an open access journal, considers original research studies that focus on theoretical ideas and models associated with(More)
— We describe several techniques for using bulk matter for special purpose computation. In each case it is necessary to use an evolutionary algorithm to program the substrate on which the computation is to take place. In addition, the computation comes about as a result of nearest neighbour interactions at the nano-micro-and meso-scale. In our first example(More)
Experimental results from adaptive learning using an optically controlled neural network are presented. The authors have used example problems in nonlinear system identification and signal prediction, two areas of potential neural network application, to study the capabilities of analog neural hardware. These experiments investigated the effects of a(More)
We are proposing an innovative approach to neural computation with applications to adaptive robots. This approach will enable robots to have complex responses to unfamiliar situations without the need for either a computationally intensive central processor or preprogrammed prior anticipation of all possible situations. Conventional robots achieve adaptive(More)
We u s e e v olutionary search to nd automatically electronic circuits that toggle an output line at, or close to, a given target frequency. Reconngurable hardware in the form of eld-programmable gate arrays|as opposed to circuit simulation|computes the tness of a circuit which guides the evolutionary search. We nd empirically that oscillating circuits can(More)
We describe experimental results to demonstrate the wide-ranging computational ability of quasiperiodic oscillators built from rings of differentiating Schmitt triggers. We describe a theoretical model based on necklace functions to compute the number of states supportable by a ring circuit of a given size. Experimental results are presented to demonstrate(More)
In this paper we provide a review of selected mathematical ideas that can help us better understand the boundary between living and non-living systems. We focus on group theory and abstract algebra applied to molecular systems biology. Throughout this paper we briefly describe possible open problems. In connection with the genetic code we propose that it(More)
In this paper we propose a chemical physics mechanism for the initiation of the glycolytic switch commonly known as the Warburg hypothesis, whereby glycolytic activity terminating in lactate continues even in well-oxygenated cells. We show that this may result in cancer via mitotic failure, recasting the current conception of the Warburg effect as a(More)