Eduardo T. Katayama

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Reelin is a key mediator of ordered neuronal alignment in the brain. Here, we demonstrate that Reelin molecules assemble with each other to form a huge protein complex both in vitro and in vivo. The Reelin-Reelin interaction clearly is inhibited by the function-blocking anti-Reelin antibody, CR-50, at a concentration known to inhibit Reelin function. This(More)
We used quick-freeze deep-etch replica electron microscopy to visualize the native structure of inositol-1,4,5-trisphosphate receptor (IP3R) in the cell. In the dendrites of Purkinje neurons of bovine cerebellum there were many vesicular organelles whose surfaces were covered with a two-dimensional crystalline array of molecules. Detailed examination of the(More)
Since mica is a substitute for glass in the in vitro actin motility assay, I examined the structure of heavy meromyosin (HMM) crossbridges supporting actin filaments by quick-freeze deep-etch replica electron microscopy. This method was capable of resolving the inter-domain cleft of the monomeric actin molecule. HMM heads that are not bound to actin, when(More)
Agile software development methods have been increasingly adopted worldwide and became one of the mainstream software development approaches. Agile methods have also had an impact on software engineering education with universities adapting their courses to accommodate this new point of view of software development. Software engineering research has tried(More)
—Agile Software Development methods have been increasingly adopted worldwide and became one of the mainstream software development approaches. Agile methods have also had an impact on software engineering education with universities adapting their courses to accommodate this new point of view of software development. Software engineering research has tried(More)
Agile software development methods have been increasingly adopted worldwide and became one of the mainstream software development approaches. Agile methods have also had an impact on software engineering education with universities adapting their courses to accommodate this new form of software development. Software engineering research has tried to(More)
With quick-freeze deep-etch electron microscopy coupled with mica-flake technique, I showed previously that myosin subfragment-1 (S1) attached to F-actin in the presence of ATP is short and rounded, in contrast to its elongated and tilted appearance under rigor condition [J. Biochem. 106, 751-770 (1989)]. I further indicated that each head of heavy(More)
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