Eduardo Martínez Graciá

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It has been increasingly recognized that homogeneously staining regions (hsr) in human cancers may be complex structures composed of large amplified DNA domains containing multiple genes. It is therefore important to devise strategies for the rapid isolation of cDNAs expressed from these structures. Using a procedure we term microdissection mediated cDNA(More)
Chromosome abnormalities in human malignancies have identified the genomic location of several important growth-regulatory genes, including cellular oncogenes and tumour suppressor genes. Melanomas are characterized by recurring chromosome alterations, and it is important to identify those genes whose altered expression may be causally related to(More)
Aluminum foils were anodized in sulfuric acid solution to form thick porous anodic aluminum oxide (AAO) films of thickness approximately 6 microm. Electrodes of carboxyl-functionalized single-wall carbon nanotube (SWCNT) thin films were inkjet printed on the anodic oxide layer and the electrical characteristics of the as-obtained SWCNT-AAO-Al structures(More)
Despite dramatic advances in the identification of human expressed sequence tags (ESTs), techniques that facilitate isolation of chromosome or chromosome band-specific ESTs would be of considerable value. This report demonstrates the feasibility of identifying chromosome-specific ESTs following microdissection of a single-copy chromosome region. For this(More)
People are increasingly demanding rich-media and bundled services. However, the diverse terminals, heterogeneous networks as well as various user requirements constrain the multimedia access to low quality in the pervasive computing environment. In order to enable rich-media delivery across a wide range of devices and networks, multimedia adaptation with(More)
Recently acquired swath-bathymetry data and high-resolution seismic reflection profiles offshore Adra (Almerı́a, Spain) reveal the surficial expression of a NW– SE trending 20 km-long fault, which we termed the Adra Fault. Seismic imaging across the structure depicts a subvertical fault reaching the seafloor surface and slightly dipping to the NE showing an(More)
Chromosome microdissection is an extremely useful molecular cytogenetic tool for the characterization of chromosomal abnormalities in tumor cells. Although it has been used primarily in conjunction with fluorescence in situ hybridization (FISH), microdissection has also been useful for molecular analysis via microclone library construction. Recently,(More)
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