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Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses.
TLDR
The findings that HIV-1 downregulates autophagy and impedes immune functions of DCs represent a pathogenesis mechanism that can be pharmacologically countered with therapeutic and prophylactic implications. Expand
HIV‐1 Trafficking to the Dendritic Cell–T‐Cell Infectious Synapse Uses a Pathway of Tetraspanin Sorting to the Immunological Synapse
TLDR
The results indicate that HIV‐1 is internalized into a non‐conventional, non‐lysosomal, endocytic compartment in mDCs and suggest that HIV-1 is able to selectively subvert components of the intracellular trafficking machinery required for formation of the DC–T‐cell immunological synapse to facilitate its own cell‐to‐cell transfer and propagation. Expand
DC-SIGN–mediated Infectious Synapse Formation Enhances X4 HIV-1 Transmission from Dendritic Cells to T Cells
TLDR
It is demonstrated that DC-SIGN is required downstream from viral capture for the formation of the infectious synapse between DCs and T cells, and a novel explanation for the role ofDC-SIGN in the transfer and enhancement of HIV infection from DCs to T cells is provided. Expand
Lentivirus-Mediated RNA Interference of DC-SIGN Expression Inhibits Human Immunodeficiency Virus Transmission from Dendritic Cells to T Cells
TLDR
ShRNA-expressing lentiviral vectors capable of conditionally suppressing DC-SIGN expression were developed and should have broad applications for studying the function ofDC-SIGN in the pathogenesis of HIV as well as other pathogens also recognized by this receptor. Expand
HIV-1 activates Cdc42 and induces membrane extensions in immature dendritic cells to facilitate cell-to-cell virus propagation.
TLDR
HIV-1 binding on immature dendritic cells enhances the formation of membrane extensions that facilitate HIV-1 transfer to CD4(+) T lymphocytes, and ion abrasion scanning electron microscopy showed that cellular extensions from immature d endritic cells that have the appearance of thin filopodia in thin section images are indeed extended membranous sheets with a narrow cross section. Expand
HIV‐1 Replication in Dendritic Cells Occurs Through a Tetraspanin‐Containing Compartment Enriched in AP‐3
TLDR
A role for AP‐3 in HIV replication in a tetraspanin‐rich compartment in DC is demonstrated and contributed to the elucidation of the trafficking pathways required for DC–T cell transfer of HIV‐1 infection, a critical step during the early events of HIV infection. Expand
Competition between the Sendai Virus N mRNA Start Site and the Genome 3′-End Promoter for Viral RNA Polymerase
TLDR
The manner in which this competition could occur for polymerase off the template and polymerase on the template adds insight into how the viral RNA polymerase switches between its dual functions as transcriptase and replicase. Expand
HIV interaction with endosomes in macrophages and dendritic cells.
TLDR
It is shown that macrophages infected with HIV contain large intracellular pools of infectious virus that can be released by homogenisation of intact cells and Immunoprecipitation experiments indicate this virus has a similar complement of cellular membrane proteins to viruses that can been recovered from the extracellular medium. Expand
IgG Opsonization of HIV Impedes Provirus Formation in and Infection of Dendritic Cells and Subsequent Long-Term Transfer to T Cells1
TLDR
The intracellular fate and transmission of immune-complexed HIV seems to differ depending on time and opsonization pattern. Expand
Microbicides and other topical agents in the prevention of HIV and sexually transmitted infections
TLDR
With concerted efforts directed towards developing efficient microbicides, topical anti-infective compounds may well become a new weapon against sexually transmitted infections, including HIV, in everyday clinical practice. Expand
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