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  • Saeid Taheri, Eduardo Candelario-Jalil, Eduardo Y. Estrada, Gary A Rosenberg
  • Chemistry, Medicine
  • PloS one
  • 2009 (First Publication: 11 August 2009)
  • Variations in apparent diffusion coefficient of water (ADC) and blood-brain barrier (BBB) permeability after ischemia have been suggested, though the correlation between ADC alterations and BBBContinue Reading
  • Carla Ribeiro Alvares Batista, Giovanni Freitas Gomes, Eduardo Candelario-Jalil, Bernd L Fiebich, Antônio C P de Oliveira
  • Biology, Medicine
  • International journal of molecular sciences
  • 2019 (First Publication: 9 May 2019)
  • A large body of experimental evidence suggests that neuroinflammation is a key pathological event triggering and perpetuating the neurodegenerative process associated with many neurological diseases.Continue Reading
  • Jan C. Frankowski, Kelly M. DeMars, +5 authors Eduardo Candelario-Jalil
  • Medicine, Biology
  • Scientific reports
  • 2015 (First Publication: 1 December 2015)
  • Cyclooxygenase-2 (COX-2) is activated in response to ischemia and significantly contributes to the neuroinflammatory process. Accumulation of COX-2-derived prostaglandin E2 (PGE2) parallels theContinue Reading
    BackgroundMatrix metalloproteinases are important factors in the molecular mechanisms leading to neuronal injury in many neurological disorders. Matrix metalloproteinase (MMP)-9 is up-regulated afterContinue Reading
  • Soraya Wilke Saliba, Érica Leandro Marciano Vieira, +5 authors Antônio Carlos Pinheiro de Oliveira
  • Biology, Medicine
  • Journal of Neuroinflammation
  • 2017 (First Publication: 1 December 2017)
  • BackgroundThe mammalian target of rapamycin (mTOR) is a kinase involved in a variety of physiological and pathological functions. However, the exact role of mTOR in excitotoxicity is poorlyContinue Reading
  • Kimberly E. Hawkins, Kelly M. DeMars, +9 authors Eduardo Candelario-Jalil
  • Medicine
  • Brain and behavior
  • 2017 (First Publication: 1 May 2017)
  • BACKGROUND Resolution of inflammation is an emerging new strategy to reduce damage following ischemic stroke. Lipoxin A4 (LXA 4) is an anti-inflammatory, pro-resolution lipid mediator that reducesContinue Reading
  • Kelly M. DeMars, Changjun Yang, Carolina I Castro-Rivera, Eduardo Candelario-Jalil
  • Biology, Medicine
  • Biochemical and biophysical research…
  • 2018 (First Publication: 1 February 2018)
  • Bromodomain and extraterminal (BET) proteins are essential to pro-inflammatory gene transcription. The BET family proteins, BRD2, BRD3, BRD4, and testis-specific BRDT, couple chromatin remodeling toContinue Reading