Anabel Martínez-Arán18
Carla Torrent16
Francesc Colom14
Ana González-Pinto13
Rafael Tabarés-Seisdedos12
18Anabel Martínez-Arán
16Carla Torrent
14Francesc Colom
13Ana González-Pinto
12Rafael Tabarés-Seisdedos
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BACKGROUND Numerous studies have documented high rates of functional impairment among bipolar disorder (BD) patients, even during phases of remission. However, the majority of the available instruments used to assess functioning have focused on global measures of functional recovery rather than specific domains of psychosocial functioning. In this context,(More)
Current literature on the effects of chronic stress in general health converges to the concept of allostatic load (AL). AL is the bodily 'wear and tear' that emerges with sustained allostatic states. In the field of bipolar disorder (BD), AL offers an important clue as to why patients who undergo recurrent mood episodes are clinically perceived as less(More)
Bipolar disorder is one of the most debilitating and common illnesses worldwide. Individuals with bipolar disorder frequently present to clinical services when depressed but are often misdiagnosed with unipolar depression, leading to inadequate treatment and poor outcome. Increased accuracy in diagnosing bipolar disorder, especially during depression, is(More)
"Conventional" antidepressants, such as the selective serotonin reuptake inhibitors (SSRIs), bupropion, or serotonin-norepinephrine reuptake inhibitors, are not recommended as monotherapy for bipolar depression. Although they are likely to provide effective symptom relief in combination with mood stabilizers, the risk of precipitating a switch to mania(More)
BACKGROUND Several studies using functional magnetic resonance imaging (fMRI) in bipolar disorder (BD) have been performed in the last decade. Some of them have applied novel neuroimaging techniques such as resting-state functional connectivity magnetic resonance imaging (rs-fcMRI). METHODS We reviewed the top-quality rs-fcMRI studies in BD available in(More)
BACKGROUND Bipolar depression has been found to be associated with changes in prefrontal cortex activity during performance of cognitive tasks. However, the role of task-related de-activations has been little investigated. METHOD Forty-one bipolar depressed patients and 41 matched normal controls underwent fMRI scanning while performing baseline, 1-back(More)
OBJECTIVES Manic patients have been found to show reduced activation in the prefrontal cortex and other regions during performance of cognitive tasks. However, little is known about de-activations associated with the disorder. This study aimed to examine, at the whole-brain level, abnormal patterns of task-related activation and de-activation during(More)
INTRODUCTION Aripiprazole is approved for the acute and maintenance treatment of manic and mixed episodes associated with bipolar I disorder. The aim of the present work was to review and meta-analyze the findings of all the available randomized double-blind controlled trials (RCTs) on the efficacy of aripiprazole in the treatment of bipolar disorder. (More)
BACKGROUND Little is known about how functional imaging changes in bipolar disorder relate to different phases of the illness. AIMS To compare cognitive task activation in participants with bipolar disorder examined in different phases of illness. METHOD Participants with bipolar disorder in mania (n = 38), depression (n = 38) and euthymia (n = 38), as(More)
OBJECTIVE The study aims were to address neuropsychological functioning across different states of bipolar illness and to determine relationships among clinical features, neuropsychological performance, and psychosocial functioning. METHOD Several domains of cognitive function were examined in 30 depressed bipolar patients (DSM-IV criteria for major(More)