Eduard P. P. A. Derks

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Statistical model validation tools such as cross-validation, jack-knifing model parameters and permutation tests are meant to obtain an objective assessment of the performance and stability of a statistical model. However, little is known about the performance of these tools for megavariate data sets, having, for instance, a number of variables larger than(More)
Although wheeze is common in preschool children, the underlying pathophysiology has not yet been disentangled. Volatile organic compounds (VOCs) in exhaled breath may serve as noninvasive markers of early wheeze. We aimed to assess the feasibility of VOC collection in preschool children, and to study whether a VOC profile can differentiate between children(More)
Multi-dimensional nuclear magnetic resonance experiments are an excellent means of revealing the three-dimensional structure of biomacromolecules in solution. However, the search space in the conformational analysis of biomacromolecules, using multi-dimensional NMR data, is huge and complex. This calls for global optimization techniques with good sampling(More)
This paper describes a parallel cross-validation (PCV) procedure, for testing the predictive ability of multi-layer feed-forward (MLF) neural networks models, trained by the generalized delta learning rule. The PCV program has been parallelized to operate in a local area computer network. Development and execution of the parallel application was aided by(More)
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