Eduard Kocárek

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OBJECTIVES In contrast to most human autosomal genes which are expressed biallelically, the expression of imprinted genes depends on the parental origin of the allele. Prader-Willi syndrome is a neurobehavioral disorder in which the expression of active paternal alleles of imprinted genes from chromosomal region 15q11-q13 is abolished by deletions, maternal(More)
The paper describes automated segmentation and analysis of the microscopic images resulting from fluorescence in-situ hybridiza-tion (FISH) analysis. FISH is a popular molecular cytogenetic method. The output of a single FISH analysis is a set of several tens or hundreds microscopic images — a single evaluated sample is of roughly 20mm diameter. The goal of(More)
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