Edmund W Sullivan

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Leukemia stem cells (LSCs) are thought to play a central role in the pathogenesis of acute leukemia and likely contribute to both disease initiation and relapse. Therefore, identification of agents that target LSCs is an important consideration for the development of new therapies. To this end, we have previously demonstrated that the naturally occurring(More)
Splenic function in sickle hemoglobinopathy syndromes was assessed to determine the developmental pattern of splenic dysfunction. Nonvisualization of the spleen using technetium-99 metastable (99mTc) spleen scans correlated strongly with pocked (vesiculated) RBCs greater than or equal to 3.5%. Cross-sectional analysis of pocked RBC data from 2,086 patients(More)
CASE DESCRIPTION A 7-year-old Golden Retriever was examined because of anorexia, lethargy, vomiting, and gradual weight loss. CLINICAL FINDINGS Splenomegaly, pancytopenia, high serum calcium concentration, and high alkaline phosphatase activity were detected. Magnetic resonance imaging revealed an enlarged mesenteric lymph node and increased signals from(More)
CASE DESCRIPTION A 3-year-old 10-kg (22-lb) neutered male Cavalier King Charles Spaniel was referred because of an episode of acute vomiting and diarrhea. CLINICAL FINDINGS On physical examination, mild splenomegaly and prominent submandibular and popliteal lymph nodes were detected. Complete blood cell count revealed a high WBC count, characterized by a(More)
CSF of children with leukemia treated with cranial radiation and intrathecal methotrexate (IT MTX) can shorten the recalcification time of normal plasma. Graeber postulated that this procoagulant activity of CSF reflects release of phospholipid from the demyelinating effects of central nervous system (CNS) prophylaxis. We have confirmed their findings and(More)
G RAEBER AND STUART’ reported an increase in procoagulant activity in the cerebrospinal fluid (CSF) of children with acute lymphoblastic leukemia (ALL) following prophylactic central ncrvous system (CNS) treatment with cranial radiation and intrathecal methotrexate. They postulated that the shortening of the plasma recalcification time (PRT) reflected the(More)
Leukemia stem cells (LSCs) are thought to play a central role in the pathogenesis of acute leukemia and likely contribute to both disease initiation and relapse. Therefore, identification of agents that target LSCs is an important consideration for the development of new therapies. To this end, we have previously demonstrated that the naturally-occurring(More)
A rapid and accurate means of determining the percentage of Hb S in blood would be of value in the management of sickle cell patients undergoing emergency exchange transfusions and on chronic transfusion programs. To determine the usefulness of the 2-hour SCP in predicting the % Hb S we compared the % of sickled cells in blood incubated for 2 hours in(More)
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