Edmund H Choi

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We studied the first domain of the HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci of 67 HLA-DRw8-positive Caucasians including 43 with early-onset pauciarticular juvenile rheumatoid arthritis (EOPA-JRA, alternatively known as early-onset pauciarticular juvenile chronic arthritis). Serology, restriction fragment length polymorphism (RFLP), and polymerase chain(More)
This report demonstrates a T-cell receptor (Tcr) restriction fragment length polymorphism, defined by a Tcrb-V6.1 gene probe and Bgl II restriction enzyme, to be absolutely correlated with allelic variation in the coding sequence of a Tcrb-V6.1 gene. A pair of non-conservative amino acid substitutions distinguish the Tcrb-V6.1 allelic variants. An(More)
Two alleles of beta-2 microglobulin (/32m) have been defined among laboratory strains of mice on the basis of electrophoretic migration (Michaelson et al. 1980) and antigenic variation (Chorney et al. 1982). The locus that codes for these alleles is closely linked to the H-3 histocompatibility locus on chromosome 2 (Michaelson 1981, Goding 1981, Robinson et(More)
Medial parameniscal cysts of the knee are typically 0.3 to 9 mm in diameter. Few cases of unusually large medial parameniscal cysts have been reported. We describe the treatment of a patient with osteoarthritis of the knee who presented with an extraordinarily large, ipsilateral, medial parameniscal cyst, 10 cm in diameter. We believe this to be the largest(More)
Among the major histocompatibility complex class II genes, HLA-DP is least understood in terms of its contributions to the normal immune response and to autoimmunity. The few autoimmune diseases with HLA-DP associations can provide insight into the function of HLADP. Among these diseases is one form of juvenile rheumatoid arthritis (JRA) which has been(More)
The central role of the antigen-specific alpha/beta T-cell receptor (Tcr) in immune recognition has led to a search for Tcr gene polymorphism relevant to autoimmune diseases. Previous reports primarily emphasized associations with constant (C)-region (Millward et al. 1987; Demaine et al. 1989; Freimark et al. 1987) restriction fragment lenght polymorphisms(More)
The differential diagnosis of a tibial intracortical diaphyseal lesion includes osteoid osteoma, periosteal chondroma, nonossifying fibroma, osteofibrous dysplasia, and adamantinoma. While osteoid osteomas represent 5% of all primary bone tumors, little is understood about intracortical chondromas. Intracortical chondroma was first described in 1990 and 7(More)
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