Learn More
BACKGROUND Better understanding of complications and outcomes of adults hospitalized with respiratory syncytial virus (RSV) infection is necessary. METHODS A retrospective cohort study was conducted on all adults (≥ 18 years) admitted to 3 acute care general hospitals in Hong Kong with virologically confirmed RSV infection during 2009-2011 (N = 607).(More)
Molecular switches gate many fundamental processes in natural and artificial systems. Here, we report the development of an electrochemical platform in which a proton carrier switches the activity of a catalyst. By incorporating an alkyl phosphate in the lipid layer of a hybrid bilayer membrane, we regulate proton transport to a Cu-based molecular oxygen(More)
In this report, we use a hybrid bilayer membrane (HBM) as an electrochemical platform to study anion diffusion through a lipid monolayer. We first append lipid on a self-assembled monolayer (SAM) that contains a covalently bound Cu(I)/Cu(II) redox center. We then perform cyclic voltammetry (CV) using different anions in bulk solution and extract(More)
Cu complexes of 2,2'-dipicolylamine (DPA) were prepared and tested as electrocatalysts for the oxygen reduction reaction (ORR). To study the effect of multinuclearity on the ORR, two Cu-DPA units were connected with a flexible linker, and a third metal-binding pocket was installed in the ligand framework. ORR onset potentials and the diffusion-limited(More)
A series of copper complexes based on the tris(2-pyridylmethyl)amine (TPA) ligand are examined for their oxygen reduction reaction (ORR) activity. Increasing the potential of the Cu(I/II) couple from 0.23 V vs RHE for [Cu(TPA)(L)](2+) to 0.52 V for [Cu(TEPA)(L)](2+) (tris(2-pyridylethyl)amine) at pH 7 or adding a hydrogen-bonding secondary coordination(More)
Fundamental understanding of the oxygen reduction reaction in aqueous medium at temperatures above 100 °C is lacking due to the practical limitations related to the harsh experimental conditions. In this work, the challenge to suppress water from boiling was overcome by conducting the electrochemical investigation under pressurized conditions. A striking(More)
Proton-coupled electron transfer (PCET) reactions are ubiquitous in biochemistry and alternative energy schemes. Natural enzymes utilize quinones in proton transfer chains and energy conversion processes. Here, we utilize a bio-inspired hybrid bilayer membrane system to control the reaction mechanism of a quinone molecule covalently bound to an electrode(More)
The development of non-precious-metal (NPM) catalysts to replace the Pt alloys currently used in fuel cells to facilitate the oxygen reduction reaction (ORR) is a vital step in the widespread utilization of fuel cells. Currently, the ORR mechanism for NPM catalysts is not well understood, prohibiting the design and preparation of improved NPM catalysts. We(More)
The binding properties of tetramethylpyrazine (TMPZ), a commonly used cardiovascular drug in China, to alpha 2 adrenergic receptors in human platelets were investigated. Increasing concentrations of TMPZ inhibited [3H]-yohimbine binding in intact platelets. The displacement curve was parallel to those of clonidine and yohimbine, with a Ki of 7.7 X 10(-5) M(More)
In this study, we examine the mechanism of flip-flop diffusion of proton carriers across the lipid layer of a hybrid bilayer membrane (HBM). The HBM consists of a lipid monolayer appended on top of a self-assembled monolayer containing a Cu-based O2 reduction catalyst on a Au electrode. The flip-flop diffusion rates of the proton carriers dictate the(More)