Intramolecular carbozincation of unactivated alkenes occurs through a zinc radical transfer mechanism.
- T. Cohen, H. Gibney, R. Ivanov, Edmund A.-H. Yeh, I. Marek, D. Curran
- ChemistryJournal of the American Chemical Society
- 8 November 2007
The combined findings strongly suggest that these organozinc cyclizations occur by a zinc radical transfer mechanism rather than by a conventional carbometallation that is thought to occur with the analogous organolithium and organomagnesium cyclizations.
Assignment of the structure of petrocortyne A by mixture syntheses of four candidate stereoisomers.
- Binglin Sui, Edmund A.-H. Yeh, D. Curran
- ChemistryJournal of Organic Chemistry
- 7 May 2010
Having access to all possible isomers of both petrocortyne A and its Mosher derivatives provided a secure structure assignment not so much because one of the isomers matched the natural product, but because all of the other isomers did not.
Synthesis and analysis of the all-(S) side chain of phosphomycoketides: a test of NMR predictions for saturated oligoisoprenoid stereoisomers.
- J. Buter, Edmund A.-H. Yeh, Owen W Budavich, K. Damodaran, A. Minnaard, D. Curran
- ChemistryJournal of Organic Chemistry
- 17 May 2013
The results suggest that a late-stage epimerization, not a failure of an asymmetric synthesis step, caused the formation of minor stereoisomers in the sample of pentamethylheptacosan-1-ol.
Pd-Xantphos-catalyzed direct arylation of nucleosides.
- F. Ngassa, Kyle A Dekorver, Theothora S. Melistas, Edmund A.-H. Yeh, M. Lakshman
- Chemistry, BiologyOrganic Letters
- 28 September 2006
It is demonstrated herein that Pd-Xantphos catalytic systems lead to successful N-arylation of suitably protected 2'-deoxyadenosine and 2-deoxyguanosine with a wide range of aryl bromides.
Bare-minimum fluorous mixture synthesis of a stereoisomer library of 4,8,12-trimethylnonadecanols and predictions of NMR spectra of saturated oligoisoprenoid stereoisomers.
- Edmund A.-H. Yeh, Eveline Kumli, K. Damodaran, D. Curran
- ChemistryJournal of the American Chemical Society
- 30 January 2013
All four diastereomers of a typical saturated oligoisoprenoid, 4,8,12-trimethylnonadecanol, are made by an iterative three-step cycle with the aid of traceless thionocarbonate fluorous tags to encode…