Efavirenz Promotes β-Secretase Expression and Increased Aβ1-40,42 via Oxidative Stress and Reduced Microglial Phagocytosis: Implications for HIV Associated Neurocognitive Disorders (HAND)
- Lecia A M BrownJingji Jin B. Giunta
- 23 April 2014
Biology, Environmental Science
The majority of Aβ promoting effects of this cART regimen are dependent upon EFV as it promotes both increased production, and decreased clearance of A β peptide.
Flipping the switches: CD40 and CD45 modulation of microglial activation states in HIV associated dementia (HAD)
- J. SalemiDemian F. Obregon B. Giunta
- 11 January 2011
Biology, Medicine
This property of microglial CD45 as a regulatory "off switch" for a CD40-promoted M1, APC-type microglia activation phenotype may represent a critical therapeutic target for the prevention and treatment of neurodegeneration, as well as microglian dysfunction, found in patients with HAD.
EVALUATION OF HOW CIGARETTE SMOKE IS A DIRECT RISK FACTOR FOR ALZHEIMER'S DISEASE.
A systematic review and original data support the idea that the mechanism underlying the epidemiological association of cigarette smoking with AD might involve the effect of cigarette smoke on APP processing, a reduction of Aβ clearance by microglia, and/or an increased microglial proinflammatory response.
138: DO NOT FORGET YOUR FLU SHOT AN INTERESTING CASE OF FLU MYOCARDITIS
- Edin SadicAngel I MartinHugo J Narvarte
- 2018
Medicine
DO NOT FORGET YOUR FLU SHOT: AN INTERESTING CASE OF FLU MYOCARDITIS
- Edin SadicAngel I MartinHugo J Narvarte
- 10 March 2018
Medicine
Cardiac papillary fibroelastoma
- Dominika M ZoltowskaEdin Sadic E. Missov
- 28 May 2021
Medicine
The current state of understanding regarding PFE is summarized and areas of ongoing controversy are discussed to discuss the potential for devastating clinical consequences of PFEs.
Abstract 175: Atrial Fibrillation in the USF Resident Clinics: Quality-Driven Medical Therapy
- Edin Sadic
- 1 April 2018
Medicine
Circulation: Cardiovascular Quality and Outcomes
A significant gap in care for atrial fibrillation patients at USF resident clinics is revealed, with just over half being appropriately anticoagulated, and a bundle of quality improvement methodologies are implemented.
Cardiac Amyloidosis Presenting as Biventricular Systolic Heart Failure
- Monique OyeAaron RichardsonEdin SadicAhmad AlkhasawnehG. Velarde
- 1 April 2021
Medicine
Comprehensive multimodality imaging including complete echocardiography with longitudinal strain analysis, cardiac magnetic resonance imaging, nuclear medicine pyrophosphate scan, and fat pad biopsy confirmed diagnosis of transthyretin cardiac amyloidosis.
Legionellosis in Patients With Cancer: A Retrospective Observational Study, 2005–2014
- A. YacoubEdin SadicA. FlynnMitsuya KatayamaJ. Greene
- 1 July 2015
Medicine
The study found that most patients with Legionella pneumonia in immunocompromised patients with underlying cancer are lymphopenic, with multifocal consolidation in 2 of 3 patients, and all the cases that were thought to be a mold pneumonia were diagnosed as Legionella by bronchoalveolar lavage culture or the Legionella urine antigen.
Myocardial Bridging Unmasks as an Acute Coronary Syndrome from Dehydration
- Naji MaalikiMichael OmarA. AliAmy RoemerJose RuizEdin Sadic
- 12 July 2021
Medicine
A 50-year-old male presented for loss of consciousness and a subsequent left heart catheterization revealed that the middle segment of the left anterior descending artery (LAD) demonstrated severe stenosis during systole but would become patent during diastole, which was suggestive of myocardial bridging
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