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The precorneal tear film is important in preserving the integrity of the corneal epithelium. One of several quantitative and qualitative clinical evaluation of the tear film is the determination of break-up time (BUT). Although controversial, this test is an important index of tear film physiology. The test depends upon the viscosity, surface tension and(More)
BACKGROUND Melasma is an abnormal acquired hyperpigmentation of the face of unknown origin, it is considered a single disease and very little has been found regarding its pathogenesis. It is usually assumed that melasma is due to excessive melanin production, but previous work using Raman spectroscopy showed degraded molecules of melanin in some melasma(More)
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