Edel O'toole

Publications4
h-index2
Citations91
Highly Influential Citations3
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Oral delivery of macromolecules: rationale underpinning Gastrointestinal Permeation Enhancement Technology (GIPET).
TLDR
A summary of some approaches taken to intestinal permeation enhancement is presented and the oral delivery system developed by Merrion Pharmaceuticals, Gastrointestinal Permeation Enhancement Technology (GIPET) is explored.
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Oral administration of the GnRH antagonist acyline, in a GIPET®-enhanced tablet form, acutely suppresses serum testosterone in normal men: single-dose pharmacokinetics and pharmacodynamics
TLDR
Oral administration of GIPET®-enhanced acyline significantly suppresses testosterone and gonadotropins in normal men without untoward side effects and might have utility in the management of prostate cancer.
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MER-104 tablets: a dose-ranging study of an oral formulation of a gonadotropin-releasing hormone antagonist, acyline.
TLDR
Therapeutically-effective levels of a decapeptide GnRH antagonist, acyline, can be achieved using an oral delivery platform, GIPET™, and indicate that MER-104 tablets may have potential in the treatment of prostate and breast cancer, endometriosis, prostate hypertrophy, and as part of a male contraceptive regimen.
Advancing Gastrointestinal Permeation Enhancement Formulations into the Clinic: GIPETTM
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