Eddy Karnieli

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PURPOSE Clinical practice guidelines are important instruments for improving the quality of care; in paper form, however, they are not used as effectively as possible. In order to develop a guideline-based decision support system (DSS) prototype to help clinicians deal with diabetic patients' foot problems, we drew on methodologies from qualitative(More)
Scope of the problem The overflow of scientific information has transformed the field of medicine. We are now facing an era in which in addition to the traditional medical training, medical information is readily available to professionals and to the public. Easily searched databases provide original research articles and focused reviews in seconds, and the(More)
Clinical guidelines usually need to be adapted to fit local practice before they can be actually used by clinicians. Reasons for adaptation include variations of institution setting such as type of practice and location, availability of resources, difference of patient populations, local policies, and practice patterns. When a guideline is implemented for(More)
We present a step-by-step manual for chronic cannulation of rats using a simple technique. This concept facilitates repeated clamping of the same rat over a 6-10-week period, providing a completely separate infusion route from blood sampling access which is placed into mixed venous blood in the inferior vena cava. Permanent catheters implanted into the left(More)
The insulin-responsive glucose transporter 4 (GLUT4) has a major role in glucose uptake and metabolism in insulin target tissues (i.e. adipose and muscle cells). In these tissues, the peroxisome proliferator-activated receptor (PPAR) family of nuclear receptors and the winged-helix-forkhead box class O (FOXO) family of factors are two key families of(More)
The world is facing an epidemic rise in diabetes mellitus (DM) incidence, which is challenging health funders, health systems, clinicians, and patients to understand and respond to a flood of research and knowledge. Evidence-based guidelines provide uniform management recommendations for "average" patients that rarely take into account individual variation(More)
BACKGROUND Obesity is common in type 2 diabetes (T2DM) and is associated with increased risk of morbidity and all-cause mortality. This analysis describes weight changes associated with insulin detemir initiation in real-life clinical practice. METHODS Study of Once-Daily Levemir (SOLVE) was a 24-week international observational study of once-daily(More)
OBJECTIVES Older patients are particularly vulnerable to hypoglycaemia. The aim of this study was to evaluate the response to initiation of once-daily insulin detemir in patients aged ≥75 years with type 2 diabetes mellitus (T2DM) treated with one or more oral antidiabetic drugs (OADs). METHODS A sub-analysis was conducted using data from SOLVE (Study of(More)