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The mevalonate pathway and the glyceraldehyde 3-phosphate (GAP)-pyruvate pathway are alternative routes for the biosynthesis of the central isoprenoid precursor, isopentenyl diphosphate. Genomic analysis revealed that the staphylococci, streptococci, and enterococci possess genes predicted to encode all of the enzymes of the mevalonate pathway and not the(More)
Many bacteria employ the nonmevalonate pathway for synthesis of isopentenyl diphosphate, the monomer unit for isoprenoid biosynthesis. However, gram-positive cocci exclusively use the mevalonate pathway, which is essential for their growth (E. I. Wilding et al., J. Bacteriol. 182:4319-4327, 2000). Enzymes of the mevalonate pathway are thus potential targets(More)
  • Bridson Nc, Fraser Cs, Herron Je, Wilding El Electrophysiological, Ed Wilding
  • 2011
In a series of studies, we investigated boundary conditions for when memory retrieval can be restricted successfully to task-relevant information. We exploited the fact that scalp-recorded electrophysiological indices of episodic retrieval processes can act as indicators of the conditions under which remembering is controlled. Our work suggests that(More)
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