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A global picture of gene expression in the common immune-mediated skin disease, psoriasis, was obtained by interrogating the full set of Affymetrix GeneChips with psoriatic and control skin samples. We identified 1,338 genes with potential roles in psoriasis pathogenesis/maintenance and revealed many perturbed biological processes. A novel method for(More)
Sequencing of full-insert clones from full-length cDNA libraries from both Xenopus laevis and Xenopus tropicalis has been ongoing as part of the Xenopus Gene Collection Initiative. Here we present 10,967 full ORF verified cDNA clones (8049 from X. laevis and 2918 from X. tropicalis) as a community resource. Because the genome of X. laevis, but not X.(More)
BACKGROUND Mutations and promoters' methylation of a set of candidate cancer genes (CAN genes) are associated with progression of colorectal cancer (CRC). We hypothesized that these genes' promoters are inactivated through epigenetic silencing and may show a different profile in high-risk populations. We investigated the status of CAN gene methylation and(More)
There is sudden and dramatic visual function deterioration in 1–10 % of eyes filled with silicone oil at the time of removal of silicon oil. Transmission of high-energy blue light is increased in eyes filled with silicone oil. We sought to identify if increased foveal light exposure is a potential factor in the pathophysiology of the visual loss at the time(More)
SUMMARY Apollo is a genome annotation-editing tool with an easy to use graphical interface. It is a component of the GMOD project, with ongoing development driven by the community. Recent additions to the software include support for the generic feature format version 3 (GFF3), continuous transcriptome data, a full Chado database interface, integration with(More)
eveloping applications with scl phisticated user interfaces is a D complex and time-consuming task. Studies have shown that 50 to 80 percent of the code for these applications deal with user-interface issues. The variety and mercurial nature of the p r e gramming interfaces to existing userinterface systems creates another prob lem. The demand for qualified(More)
Until recently, little consideration was placed on the integrity of the subscapularis tendon after total shoulder arthroplasty. We have noted that several of our patients exhibited loss of internal rotation strength and subscapularis function after total shoulder arthroplasty utilizing an anatomic soft tissue repair of the subscapularis, both with and(More)
  • Ed Lee
  • 2009 IEEE Custom Integrated Circuits Conference
  • 2009
The integration of CMOS circuits with sensors and MEMS technologies is changing the paradigm leading to systems on chips. These systems support a very diverse range of applications in communications, harsh environment sensing, and imaging. The applications of circuits for backend stimulation of biological tissue, and intracortical sensing enable critical(More)
A56-year-old HIV-positive man presented to the hospital with a random blood glucose level of 27.4 mmol/L and a 3-week history of polyuria, polydipsia and polyphagia, accompanied by weight loss, fatigue, weakness and blurred vision. There were no symptoms of infection. The patient had been diagnosed with HIV infection 7 years previously. His medical history(More)