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Cytogenetic classification of 350 adults with acute lymphoblastic leukaemia on MRC UKALL XA trial showed the following statistically significant associations: t(9;22) (11%) increased with increasing age and leucocyte counts (WBC) and most had a C/pre-B immunophenotype. t(4;11) (3%) was associated with higher WBCs, increasing age and null immunophenotype.(More)
The purpose of the study was to examine the influence of age on outcome in a large cohort of children and adults with lymphoblastic leukaemia who were treated on two similar trials. Factors influencing outcome were examined in 2204 patients aged over 1 year treated between 1985 and 1992 on the parallel Medical Research Council Trials UKALL X and XA, for(More)
This study compared free flap survival rates following end-to-end and end-to-side arterial anastomoses. A groin flap was transferred to the anterior cervical region in 40 rats. There were 20 rats in each experimental group. The end-to-side group was further divided into subgroups depending on the angle of the anastomosis, which was either 60 degrees or 90(More)
OBJECTIVE To compare survival of dogs with a congenital portosystemic shunt (CPSS) that received medical or surgical treatment. DESIGN Prospective cohort study. ANIMALS 126 client-owned dogs with a single CPSS. PROCEDURES Dogs were examined at 1 of 3 referral clinics, and a single CPSS was diagnosed in each. Dogs received medical or surgical treatment(More)
BACKGROUND Pigmented basal cell carcinoma (PBCC) may occasionally be misdiagnosed as melanoma. In the Hispanic population, PBCC is common. OBJECTIVE We attempted to determine the prevalence of PBCC in a Hispanic population. METHODS A randomized, blinded, retrospective study was designed to assess histologic slides for the presence of microscopic(More)
Sophisticated procedures are now available to replace both sensory and motor loss. These are all possible through the advances in microsurgical techniques. The renewed interest in nerve repair and nerve grafting has been discussed. Improved results are now obtainable because of microsurgery. Standard neurovascular island flaps are being modified and(More)
Recently, the advantages of end-to-side anastomoses in reconstructive microvascular surgery have been emphasized. This article describes a practical laboratory model for practicing end-to-side anastomoses and a simplified technique for suturing the posterior wall in such anastomoses. The left common iliac artery of a rat is transected and an end-to-side(More)
The authors examined the patterns of mortality from ischemic heart disease and cerebrovascular disease in Australia for men and women aged 30-84 years during the period 1950-1986 to assess the relative contributions of period and cohort effects on changes in the mortality rates. Death rates for ischemic heart disease increased from 1950 to the late 1960s(More)