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Calorie restriction (CR) extends life span in diverse species. Mitochondria play a key role in CR adaptation; however, the molecular details remain elusive. We developed and applied a quantitative mass spectrometry method to probe the liver mitochondrial acetyl-proteome during CR versus control diet in mice that were wild-type or lacked the protein(More)
Polycystic ovary syndrome (PCOS) is associated with metabolic and endocrine disorders in women of reproductive age. The etiology of PCOS is still unknown. Mice prenatally treated with glucocorticoids exhibit metabolic disturbances that are similar to those seen in women with PCOS. We used an untargeted nuclear magnetic resonance (NMR)-based metabolomics(More)
Tuberculosis is a treatable but severe disease caused by Mycobacterium tuberculosis (Mtb). Recent statistics by international health organizations estimate the Mtb exposure to have reached over two billion individuals. Delay in disease diagnosis could be fatal, especially to the population at risk, such as individuals with compromised immune systems.(More)
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