#### Filter Results:

- Full text PDF available (79)

#### Publication Year

1962

2017

- This year (13)
- Last 5 years (47)
- Last 10 years (99)

#### Publication Type

#### Co-author

#### Journals and Conferences

#### Brain Region

#### Cell Type

#### Key Phrases

#### Method

#### Organism

Learn More

- Eberhard O. Voit, Jonas S. Almeida
- Bioinformatics
- 2004

RATIONALE
Modern molecular biology is generating data of unprecedented quantity and quality. Particularly exciting for biochemical pathway modeling and proteomics are comprehensive, time-dense profiles of metabolites or proteins that are measurable, for instance, with mass spectrometry, nuclear magnetic resonance or protein kinase phosphorylation. These… (More)

- I-Chun Chou, Eberhard O. Voit
- Mathematical biosciences
- 2009

The organization, regulation and dynamical responses of biological systems are in many cases too complex to allow intuitive predictions and require the support of mathematical modeling for quantitative assessments and a reliable understanding of system functioning. All steps of constructing mathematical models for biological systems are challenging, but… (More)

- Gautam Goel, I-Chun Chou, Eberhard O. Voit
- Bioinformatics
- 2008

MOTIVATION
At the center of computational systems biology are mathematical models that capture the dynamics of biological systems and offer novel insights. The bottleneck in the construction of these models is presently the identification of model parameters that make the model consistent with observed data. Dynamic flux estimation (DFE) is a novel… (More)

- Eberhard O. Voit, Tomas Radivoyevitch
- Bioinformatics
- 2000

MOTIVATION
Modern methods of genomics have produced an unprecedented amount of raw data. The interpretation and explanation of these data constitute a major, well-recognized challenge.
RESULTS
Biochemical Systems Theory (BST) is the mathematical basis of a well-established methodological framework for analyzing networks of biochemical reactions. An… (More)

- Marco Vilela, I-Chun Chou, Susana Vinga, Ana Tereza Ribeiro de Vasconcelos, Eberhard O. Voit, Jonas S. Almeida
- BMC Systems Biology
- 2008

The inverse problem of identifying the topology of biological networks from their time series responses is a cornerstone challenge in systems biology. We tackle this challenge here through the parameterization of S-system models. It was previously shown that parameter identification can be performed as an optimization based on the decoupling of the… (More)

- Eberhard O. Voit, Ana Rute Neves, Helena Santos
- Proceedings of the National Academy of Sciences…
- 2006

The combination of high-throughput methods of molecular biology with advanced mathematical and computational techniques has propelled the emergent field of systems biology into a position of prominence. Unthinkable a decade ago, it has become possible to screen and analyze the expression of entire genomes, simultaneously assess large numbers of proteins and… (More)

- Eberhard O. Voit, Jackson R G S Almeida, +4 authors Helena Santos
- Systems biology
- 2006

The unexpectedly long, and still unfinished, path towards a reliable mathematical model of glycolysis and its regulation in Lactococcus lactis is described. The model of this comparatively simple pathway was to be deduced from in vivo nuclear magnetic resonance time-series measurements of the key glycolytic metabolites. As to be expected from any nonlinear… (More)

Mathematical models have become a necessary tool for organizing the rapidly increasing amounts of large-scale data on biochemical pathways and for advanced evaluation of their structure and regulation. Most of these models have addressed specific pathways using either stoichiometric or flux-balance analysis, or fully kinetic Michaelis-Menten… (More)

- Joshua S. Weitz, Yuriy Mileyko, Richard I. Joh, Eberhard O. Voit
- Biophysical journal
- 2008

For many bacterial viruses, the choice of whether to kill host cells or enter a latent state depends on the multiplicity of coinfection. Here, we present a mathematical theory of how bacterial viruses can make collective decisions concerning the fate of infected cells. We base our theory on mechanistic models of gene regulatory dynamics. Unlike most… (More)

- I-Chun Chou, Harald Martens, Eberhard O. Voit
- Theoretical Biology and Medical Modelling
- 2006

The estimation of parameter values continues to be the bottleneck of the computational analysis of biological systems. It is therefore necessary to develop improved methods that are effective, fast, and scalable. We show here that alternating regression (AR), applied to S-system models and combined with methods for decoupling systems of differential… (More)