Eberhard Fritz

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Radiotherapy is a powerful cure for several types of solid tumours, but its application is often limited because of severe side effects in individual patients. With the aim to find biomarkers capable of predicting normal tissue side reactions we analysed the radiation responses of cells from individual head and neck tumour and breast cancer patients of(More)
Wolfram Syndrome is an autosomal recessive degenerative disorder of the neuroendocrine system. Diabetes mellitus is its lead symptom. Patients show mutations in the wolframin (WFS1) gene coding for a hydrophobic transmembrane protein of 890 amino acids. This protein was preliminarily localised in the endoplasmatic reticulum (ER) in cells of mice and rats.(More)
During secondary immunoglobulin (Ig) diversification in vertebrates, the sequence of the variable region of Ig genes may be altered by templated or non-templated mechanisms. In both cases, cytidine deamination by activation-induced cytidine deaminase (AID) in the transcribed Ig loci leads to DNA lesions, which are repaired by conservative homologous(More)
In this study we investigated the effects of short term (ST, 24 h, 100 mM NaCl) and long term (LT) salinity (4 weeks, NaCl increased weekly from 100 to 400 mM) on leaf abscisic acid (ABA), calmodulin (CaM) and activity of antioxidant enzymes (superoxide dismutase, SOD; peroxidase, POD) in 1-year-old seedlings of two mangrove species, Kandelia candel and(More)
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