Eberhard Daniel Pracht

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This paper describes imaging of lung function with oxygen-enhanced MRI using dynamically acquired T 1 parameter maps, which allows an accurate, quantitative assessment of time constants of T 1-enhancement and therefore lung function. Eight healthy volunteers were examined on a 1.5-T whole-body scanner. Lung T 1-maps based on an IR Snapshot FLASH technique(More)
Magnetic susceptibility gradients caused by tissue/air interfaces lead to very short T(2)* times in the human lung. These susceptibility gradients are dependent on the magnetic susceptibility of the respiratory gas and therefore should influence T(2)* relaxation. In this work, a technique for quantitative T(2)* mapping of the human lung during one breath(More)
PURPOSE To demonstrate that the use of nonquantitative methods in oxygen-enhanced (OE) lung imaging can be problematic and to present a new approach for quantitative OE lung imaging, which fulfills the requirements for easy application in clinical practice. MATERIALS AND METHODS A total of 10 healthy volunteers and three non-small-cell lung cancer (NSCLC)(More)
PURPOSE To develop a magnetization transfer (MT) module in conjunction with a single-shot MRI readout technique and to investigate the MT phenomenon in non-small-cell lung cancer (NSCLC) as an adjunct for radiation therapy planning. MATERIALS AND METHODS A total of 10 patients with inoperable NSCLC were investigated using a 1.5T MR scanner. MT ratio (MTR)(More)
Conductive implants are in most cases a strict contraindication for MRI examinations, as RF pulses applied during the MRI measurement can lead to severe heating of the surrounding tissue. Understanding and mapping of these heating effects is therefore crucial for determining the circumstances under which patient examinations are safe. The use of fluoroptic(More)
Intermolecular zero-quantum coherences are insensitive to magnetic field inhomogeneities. For this reason we have applied the HOMOGENIZED sequence [Vathyam et al., Science 272 (1996) 92] to phantoms containing metabolites at low concentrations, phantoms with air inclusions, an intact grape, and the head of a rat in vivo at 750 MHz. In the 1H-spectra, the(More)
This work introduces an MR-compatible active breathing control device (MR-ABC) that can be applied to lung imaging. An MR-ABC consists of a pneumotachograph for respiratory monitoring and an airway-sealing unit. Using an MR-ABC, the subjects were forced to suspend breathing for short time intervals, which were used in turn for data acquisition. While the(More)
Respiratory motion and pulsatile blood flow can generate artifacts in morphological and functional lung imaging. Total acquisition time, and thus the achievable signal to noise ratio, is limited when performing breath-hold and/or electrocardiogram-triggered imaging. To overcome these limitations, imaging during free respiration can be performed using(More)
PURPOSE To present a single-shot perfusion imaging sequence that does not require contrast agents or a subtraction of a tag and a control image to create the perfusion-weighted contrast. The proposed method is based on SEEPAGE. MATERIALS AND METHODS Experiments with healthy volunteers were performed to qualitatively and quantitatively obtain pulmonary(More)
Implementation of an accelerated Magnetization Prepared RApid Gradient Echo (MP-RAGE) sequence for T1 weighted neuroimaging; exploiting modern MRI technologies to minimize scan time while preserving the image quality. A custom MP-RAGE sequence was implemented on a state-of-the-art 3T MR scanner equipped with a 32-channel receiver array head coil. The(More)