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The efforts towards peptide nucleic acid (PNA) drug discovery using cellular RNAs as molecular targets is briefly reviewed, with special emphasis on recent developments. Special attention is given to cellular delivery in vivo bioavailability and the possibilities of using PNA oligomers to (re)direct alternative splicing of pre-messenger (m)RNA.
Mycoplasma hyopharyngis is a seldom isolated porcine species. It was found, adequately described , and named by Erickson et al. (1986). In that study 7 strains were isolated from the upper respiratory tract of pigs in 2 different herds, one of which was an institutional herd. All the strains fulfilled the usual criteria put up for characterization of… (More)