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Chk1 is phosphorylated within its C-terminal regulatory domain by the upstream ATM/ATR kinases during checkpoint activation; however, how this modulates Chk1 function is poorly understood. Here, we show that Chk1 kinase activity is rapidly stimulated in a cell-cycle phase-specific manner in response to both DNA damage and replication arrest, and that the(More)
Studying the uptake of cell-penetrating peptides. Retro-inversion of certain cell-penetrating peptides causes severe cellular toxicity. Novel, Cell–Penetrating molecular transporters with flexible backbones and permanently charged side chains. c-Jun supports ribosomal RNA processing and nucleolar localiza-tion of RNA helicase DDX21. Distinct uptake routes(More)
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