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Tuberculosis (TB) enhances human immunodeficiency virus-1 (HIV-1) activity in patients with dual HIV-1/TB infection. Therapies that control augmentations of HIV-1 activity at sites of Mycobacterium tuberculosis (MTB) infection may be useful in inhibition of viral expansion. Regulated upon activation, normal T-cell expressed and secreted (RANTES) analogues(More)
Methods We proposed a CTL-based 'Conserved Element' (CE)-vaccine exclusively composed of nearly invariant viral segments. We reason that an efficacious vaccine must elicit responses toward HIV-1 segments that cannot mutate without severely compromising viral viability, and must not elicit responses against variable, immunodominant 'decoys'. Based on known(More)
Methods Individual viruses (20) were evaluated for differential tropism in cellular assays (PBMC, monocyte-derived macrophages, PM1, TZM-bl cells, dendritic cells and dendritic cell-T cell trans-infection) and explant tissue assays, (ectocervix, penile glans, rectal and tonsil). Relative replication of each virus among the different models was assessed by(More)
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