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A material-based bottom-up approach is proposed towards an assembly of cells and engineered micro-objects at the macroscale. We show how shape, size and wettability of engineered micro-objects play an important role in the behavior of cells on these objects. This approach can, among other applications, be used as a tool to engineer complex 3D tissues of(More)
Methods We proposed a CTL-based 'Conserved Element' (CE)-vaccine exclusively composed of nearly invariant viral segments. We reason that an efficacious vaccine must elicit responses toward HIV-1 segments that cannot mutate without severely compromising viral viability, and must not elicit responses against variable, immunodominant 'decoys'. Based on known(More)
Tuberculosis (TB) enhances human immunodeficiency virus-1 (HIV-1) activity in patients with dual HIV-1/TB infection. Therapies that control augmentations of HIV-1 activity at sites of Mycobacterium tuberculosis (MTB) infection may be useful in inhibition of viral expansion. Regulated upon activation, normal T-cell expressed and secreted (RANTES) analogues(More)
Methods Individual viruses (20) were evaluated for differential tropism in cellular assays (PBMC, monocyte-derived macrophages, PM1, TZM-bl cells, dendritic cells and dendritic cell-T cell trans-infection) and explant tissue assays, (ectocervix, penile glans, rectal and tonsil). Relative replication of each virus among the different models was assessed by(More)
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